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PINK1

PTEN induced putative kinase 1

Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582).

Gene Name: PTEN induced putative kinase 1
Family/Subfamily: Protein Kinase , NFK
Synonyms: PINK1, BRPK, PTEN induced putative kinase 1, PARK6, PTEN-induced putative kinase, Protein kinase BRPK
Target Sequences: NM_032409 NP_115785.1 Q9BXM7

Publications (23)

1
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. Exner N, Treske B, Paquet D, Holmstrm K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 27:12413-8. (WB) [PubMed:17989306]
2
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ. Human molecular genetics. 2008 17:602-16. [PubMed:18003639]
3
Characterization of PINK1 processing, stability, and subcellular localization. Lin W, Kang UJ. Journal of neurochemistry. 2008 106:464-74. (WB; Human) [PubMed:18397367]
4
The kinase domain of mitochondrial PINK1 faces the cytoplasm. Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C, Dauer W, Schon EA, Przedborski S. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:12022-7. [PubMed:18687899] [PMC:PMC2575334]
5
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. Liu W, Vives-Bauza C, Acn-Perz- R, Yamamoto A, Tan Y, Li Y, Magran J, Stavarache MA, Shaffer S, Chang S, Kaplitt MG, Huang XY, Beal MF, Manfredi G, Li C. PloS one. 2009 4:e4597. [PubMed:19242547] [PMC:PMC2644779]
6
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lmmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, Winklhofer KF. The Journal of biological chemistry. 2009 284:22938-51. [PubMed:19546216] [PMC:PMC2755701]
7
Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. Cui M, Tang X, Christian WV, Yoon Y, Tieu K. The Journal of biological chemistry. 2010 285:11740-52. [PubMed:20164189] [PMC:PMC2857048]
8
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park. Human molecular genetics. 2010 19:3734-46. (WB; Mouse) [PubMed:20639397]
9
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F. Science (New York, N.Y.). 2010 329:1215-8. [PubMed:20688984] [PMC:PMC3031172]
10
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Geisler S, Holmstrm KM, Treis A, Skujat D, Weber SS, Fiesel FC, Kahle PJ, Springer W. Autophagy. 2010 6:871-8. (WB; Human) [PubMed:20798600]
11
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. Meissner C, Lorenz H, Weihofen A, Selkoe DJ, Lemberg MK. Journal of neurochemistry. 2011 117:856-67. [PubMed:21426348]
12
Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease. Dagda RK, Gusdon AM, Pien I, Strack S, Green S, Li C, Van Houten B, Cherra SJ, Chu CT. Cell death and differentiation. 2011 18:1914-23. [PubMed:21637291] [PMC:PMC3177020]
13
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy. Mitsuhashi S, Hatakeyama H, Karahashi M, Koumura T, Nonaka I, Hayashi YK, Noguchi S, Sher RB, Nakagawa Y, Manfredi G, Goto Y, Cox GA, Nishino I. Human molecular genetics. 2011 20:3841-51. (ICC, IHC; Mouse) [PubMed:21750112] [PMC:PMC3168292]
14
Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease. Yasuda T, Hayakawa H, Nihira T, Ren YR, Nakata Y, Nagai M, Hattori N, Miyake K, Takada M, Shimada T, Mizuno Y, Mochizuki H. Journal of neuropathology and experimental neurology. 2011 70:686-97. (WB; Mouse) [PubMed:21760537]
15
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM. Open biology. 2012 2:120080. (WB; Human) [PubMed:22724072] [PMC:PMC3376738]
16
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Okatsu K, Oka T, Iguchi M, Imamura K, Kosako H, Tani N, Kimura M, Go E, Koyano F, Funayama M, Shiba-Fukushima K, Sato S, Shimizu H, Fukunaga Y, Taniguchi H, Komatsu M, Hattori N, Mihara K, Tanaka K, Matsuda N. Nature communications. 2012 3:1016. (ICC, WB; Mouse, Human) [PubMed:22910362] [PMC:PMC3432468]
17
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. Sekine S, Kanamaru Y, Koike M, Nishihara A, Okada M, Kinoshita H, Kamiyama M, Maruyama J, Uchiyama Y, Ishihara N, Takeda K, Ichijo H. The Journal of biological chemistry. 2012 287:34635-45. [PubMed:22915595] [PMC:PMC3464569]
18
The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease. Wood-Kaczmar A, Deas E, Wood NW, Abramov AY. Advances in experimental medicine and biology. 2013 961:241-9. (ICC; Human) [PubMed:23224884]
19
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Shiba-Fukushima K, Imai Y, Yoshida S, Ishihama Y, Kanao T, Sato S, Hattori N. Scientific reports. 2012 2:1002. (WB; Mouse) [PubMed:23256036] [PMC:PMC3525937]
20
Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila. Song S, Jang S, Park J, Bang S, Choi S, Kwon KY, Zhuang X, Kim E, Chung J. The Journal of biological chemistry. 2013 288:5660-72. (ICC, WB; Human) [PubMed:23303188] [PMC:PMC3581423]
21
Mitochondrial Reprogramming Regulates Breast Cancer Progression. Kannan A, Wells RB, Sivakumar S, Komatsu S, Singh KP, Samten B, Philley JV, Sauter ER, Ikebe M, Idell S, Gupta S, Dasgupta S. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 22:3348-60. (WB; Human) [Full Text Article] [PubMed:26888829]
22
Complex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression. Philley JV, Kannan A, Qin W, Sauter ER, Ikebe M, Hertweck KL, Troyer DA, Semmes OJ, Dasgupta S. Journal of cellular physiology. 2016 June;231:1364-74. [Full Text Article] [PubMed:26530043] [PMC:PMC5741292]
23
Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy. Koji Yamano, Reika Kikuchi, Waka Kojima, Ryota Hayashida, Fumika Koyano, Junko Kawawaki, Takuji Shoda, Yosuke Demizu, Mikihiko Naito, Keiji Tanaka, Noriyuki Matsuda. The Journal of cell biology. 2020 September;219: [Full Text Article] [PubMed:32556086] [PMC:PMC7480101] Related Antibodies: LS-C96472.
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PINK1 Antibody - PINK1 Monoclonal Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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PINK1 Antibody (clone 38CT18.7) LS-C96472
(4.0) Rating
(1) Publication(s)
PINK1 Mouse anti-Human Monoclonal (38CT18.7) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$393
PINK1 Antibody - Anti-PINK1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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IHC-plus™ PINK1 Antibody (aa484-504) LS-B1502
(4.0) Rating
PINK1 Rabbit anti-Human Polyclonal (aa484-504) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
1 Each/$485
PINK1 Antibody - Immunofluorescence analysis of HeLa cell using PINK1 antibody. Blue: DAPI for nuclear staining.
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PINK1 Antibody LS-C346251
PINK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PINK1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IHC-plus™ PINK1 Antibody LS-B12148
(4.0) Rating
PINK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
PINK1 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IHC-plus™ PINK1 Antibody (aa350-500) LS-B14185
(4.0) Rating
PINK1 Rabbit anti-Human Polyclonal (aa350-500) Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
0.1 ml/$460
PINK1 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PINK1 Antibody (aa350-500, Biotin) LS-C143547
PINK1 Rabbit anti-Human Polyclonal (aa350-500) (Biotin) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
Biotin Conjugated
0.1 ml/$416
PINK1 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PINK1 Antibody (aa350-500, DY488) LS-C143549
PINK1 Rabbit anti-Human Polyclonal (aa350-500) (DY488) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
DY488 Conjugated
0.1 ml/$416
PINK1 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PINK1 Antibody (aa350-500, DY650) LS-C143548
PINK1 Rabbit anti-Human Polyclonal (aa350-500) (DY650) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
DY650 Conjugated
0.1 ml/$416
PINK1 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PINK1 Antibody (aa350-500, DY550) LS-C143551
PINK1 Rabbit anti-Human Polyclonal (aa350-500) (DY550) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
DY550 Conjugated
0.1 ml/$416
PINK1 Antibody - Western blot of Park6 (PINK1) C-term in mouse kidney tissue lysates (35 ug/lane). Park6 (arrow) was detected using the purified antibody.
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PINK1 Antibody (aa493-526) LS-C163368
PINK1 Rabbit anti-Human Polyclonal (aa493-526) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
PINK1 Protein
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Human PINK1 Protein (Recombinant) - LS-G1463
E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
PINK1 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PINK1 Antibody (aa91-140) LS-B12030
PINK1 Rabbit anti-Human Polyclonal (aa91-140) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PINK1 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PINK1 Antibody (aa91-140, HRP) LS-C470782
PINK1 Rabbit anti-Human Polyclonal (aa91-140) (HRP) Antibody
Rabbit, Guinea pig, Rat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
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PINK1 Antibody (C-Terminus) LS-C47093
PINK1 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat
ELISA, WB
Unconjugated
0.1 mg/$379
PINK1 Antibody - Western blot of recombinant PINK1. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PINK1 Antibody (aa310-566) LS-C296148
PINK1 Rabbit anti-Mouse Polyclonal (aa310-566) Antibody
Mouse
WB
Unconjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
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PINK1 Antibody (aa493-526, Biotin) LS-C520416
PINK1 Rabbit anti-Human Polyclonal (aa493-526) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
PINK1 Antibody - 1:50 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PINK1 Antibody LS-C806820
PINK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PINK1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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PINK1 Antibody (aa118-147) LS-C99189
PINK1 Rabbit anti-Human Polyclonal (aa118-147) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PINK1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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Human PINK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85917
293T Cells
Myc-DDK (Flag)
54.6 kDa
20 µg/$150
PINK1 Protein - Recombinant PTEN Induced Putative Kinase 1 By SDS-PAGE
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Mouse PINK1 Protein (Recombinant His-T7) (aa310-566) - LS-G16105
E. coli
His-T7
32.3 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
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PINK1 Antibody (aa112-496, clone S4-15) LS-C209547
PINK1 Mouse anti-Human Monoclonal (aa112-496) (S4-15) Antibody
Mouse, Rat, Human
ICC, IHC, WB
Unconjugated
100 µg/$442
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PINK1 Antibody (clone 38CT20.8.5) LS-C319196
PINK1 Mouse anti-Human Monoclonal (38CT20.8.5) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
PINK1 Antibody
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PINK1 Antibody LS-C668507
PINK1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321
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PINK1 Antibody LS-C750942
PINK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$466
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PINK1 Antibody LS-C750943
PINK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$466
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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