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PIEZO1 / FAM38A
Piezo-type mechanosensitive ion channel component 1
Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship and are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensors that promote endothelial cell organization and alignment in the direction of blood flow. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.
| Gene Name: | Piezo-type mechanosensitive ion channel component 1 |
| Synonyms: | PIEZO1, KIAA0233, Protein FAM38A, Protein PIEZO1, FAM38A, Mib |
| Target Sequences: | NM_014745 NP_001136336.2 Q92508 |
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