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PIAS4 / PIASY
protein inhibitor of activated STAT, 4
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
| Gene Name: | protein inhibitor of activated STAT, 4 |
| Synonyms: | PIAS4, E3 SUMO-protein ligase PIAS4, PIAS-gamma, ZMIZ6, Piasg, PIASY |
| Target Sequences: | NM_015897 NP_056981.2 Q8N2W9 |
Publications (3)
1
The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7R surface expression. McLeod IX, Zhou X, Li QJ, Wang F, He YW. Journal of immunology (Baltimore, Md. : 1950). 2011 187:5051-61.
[PubMed:22021616]
[PMC:PMC3248807]
Related Antibodies: LS-C98800.
2
Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. Conn KL, Wasson P, McFarlane S, Tong L, Brown JR, Grant KG, Domingues P, Boutell C. Journal of virology. 2016 90:4807-26. (ICC, WB; Human)
[Full Text Article]
[PubMed:26937035]
[PMC:PMC4836348]
Related Antibodies: LS-C108719.
3
SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1. Brown JR, Conn KL, Wasson P, Charman M, Tong L, Grant K, McFarlane S, Boutell C. Journal of virology. 2016 90:5939-52. (ICC, WB; Human)
[Full Text Article]
[PubMed:27099310]
[PMC:PMC4907222]
Related Antibodies: LS-C108719.
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PIAS4 / PIASY Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
0.1 mg/$460
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa451-500) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
PIAS4 / PIASY Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
PIAS4 / PIASY Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PIAS4 / PIASY Rabbit anti-Human Polyclonal (420-500 aa, C-terminal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
PIAS4 / PIASY Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PIAS4 / PIASY Rabbit anti-Human Polyclonal (Asp488) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PIAS4 / PIASY Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Bovine, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
PIAS4 / PIASY Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa44-60) Antibody
Human, Monkey
ICC, WB
Unconjugated
100 µg/$386
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa44-73) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
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