Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Phenobarbital antibody was raised against synthetic peptide corresponding to part of the native molecule conjugated to Keyhole limpet Hemocyanin. Phenobarbital-KLH conjugated through a diazo. Linkage of m-aminophenyl barbituric acid.
Reacts with phencyclidine and displays minimal reactivity with amphetamines, benzoyl ecgonine, opiates and cannabinoids. The sensitivity of this has been calculated as < 20 ng/ml by ELISA. Phencyclidine is a dissociative drug that acts by modulating secretogranin II [sg II] expression in prefrontal cortex tissue in the absence of afferent inputs. The nature of these changes is dependent upon the duration of exposure to and/or withdrawal from phencyclidine. It is used as an anesthetic by veterinarians and is illicitly taken for its hallucinogen effects.