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PGC / Pepsin C
progastricsin (pepsinogen C)
PGC / Pepsin C is an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
| Gene Name: | progastricsin (pepsinogen C) |
| Family/Subfamily: | Protease , Aspartic A1 |
| Synonyms: | PGC, Gastricsin, Pepsinogen II, Pepsin C, Progastricsin, Pepsinogen group II, PGII, Preprogastricsin, Urinary pepsinogen 1, Pepsinogen C, Progastricsin (pepsinogen C) |
| Target Sequences: | NM_002630 NP_002621.1 P20142 |
Publications (1)
1
Regeneration of severely damaged lungs using an interventional cross-circulation platform. Brandon A Guenthart, John D O'Neill, Jinho Kim, Dawn Queen, Scott Chicotka, Kenmond Fung, Michael Simpson, Rachel Donocoff, Michael Salna, Charles C Marboe, Katherine Cunningham, Susan P Halligan, Holly M Wobma, Ahmed E Hozain, Alexander Romanov, Gordana Vunjak-Novakovic, Matthew Bacchetta. Nature communications. 2019 May;10:1985. [Full Text Article]
[PubMed:31064987]
[PMC:PMC6504972]
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PGC / Pepsin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
PGC / Pepsin C Rabbit anti-Human Polyclonal (Phe306) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PGC / Pepsin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
E. coli
8His, N-terminus
36.9 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
Sandwich
96-Well Strip Plate
Rat
4.688 - 300 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PGC / Pepsin C Goat anti-Pig Polyclonal (Biotin) Antibody
Pig
ELISA, IF, IHC, WB
Biotin Conjugated
100 µg/$896
PGC / Pepsin C Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PGC / Pepsin C Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
PGC / Pepsin C Mouse anti-Human Monoclonal (1G1H3) Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$316; 100 µg/$386
PGC / Pepsin C Rabbit anti-Human Polyclonal (aa257-306) Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PGC / Pepsin C Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (5B7-F11-F4-F3) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (Biotin) (5B7-F11-F4-F3) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (1A6-E11-E4) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (Biotin) (1A6-E11-E4) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (4A3-G4-G6) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (Biotin) (4A3-G4-G6) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (4H4-E9-E4) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (Biotin) (4H4-E9-E4) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
PGC / Pepsin C Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, IHC-P, WB
Unconjugated, Preservative Free
100 µl/$412
PGC / Pepsin C Goat anti-Pig Polyclonal (HRP) Antibody
Pig
ELISA, IHC, WB
HRP Conjugated
100 µg/$896
PGC / Pepsin C Mouse anti-Human Monoclonal (OTI1H5) Antibody
Human
Luminex
Unconjugated
100 µl/$434
PGC / Pepsin C Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
PGC / Pepsin C Rabbit anti-Human Polyclonal (aa 17-388) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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