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PERP

PERP, TP53 apoptosis effector

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.

Gene Name: PERP, TP53 apoptosis effector
Synonyms: PERP, DJ496H19.1, KCP-1, PERP, TP53 apoptosis effector, KCP1, p53-induced protein PIGPC1, THW, KRTCAP1, PIGPC1, RP3-496H19.1, Transmembrane protein THW
Target Sequences: NM_022121 NP_071404.2 Q96FX8

Publications (2)

1
PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia. Singaravelu K, Devalaraja-Narashimha K, Lastovica B, Padanilam BJ. American journal of physiology. Renal physiology. 2009 296:F847-58. [PubMed:19158346]
2
Differential gene expression in normal esophagus and Barrett's esophagus. Wang J, Qin R, Ma Y, Wu H, Peters H, Tyska M, Shaheen NJ, Chen X. Journal of gastroenterology. 2009 44:897-911. (IHC-P; Human) [PubMed:19468668] Related Antibodies: LS-B1389.

☰ Filters
Antibodies (18)
Proteins (5)
Over-Expression Lysate (2)
Primary (18)
Recombinant (3)
PERP (23)
Human (18)
Mouse (5)
Rat (4)
Bovine (4)
Dog (4)
Hamster (1)
Horse (1)
Monkey (1)
Pig (4)
IHC (10)
IHC-P (4)
WB (18)
ELISA (7)
ICC (1)
Peptide-ELISA (2)
rabbit (17)
goat (1)
Product Group
IHCPlus (2)
IgG (14)
polyclonal pc (18)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (10)
aa162-191 (7)
aa107-156 (4)
C-Terminus (1)
aa172-185 (1)
aa175-193 (1)
aa37-50 (1)
No (22)
Yes (1)
10His-SUMO, N-terminus + Myc, C-terminus (1)
GST (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
PERP Antibody - Anti-PERP antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PERP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
PERP Antibody - Anti-PERP antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PERP Goat anti-Human Polyclonal (aa172-185) Antibody
Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
Select
PERP Rabbit anti-Human Polyclonal (aa162-191) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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PERP Rabbit anti-Human Polyclonal (aa162-191) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
PERP Rabbit anti-Human Polyclonal (aa162-191) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
PERP Rabbit anti-Human Polyclonal (aa162-191) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Select
PERP Rabbit anti-Human Polyclonal (aa162-191) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
PERP Rabbit anti-Human Polyclonal (aa162-191) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
PERP Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$832
PERP Antibody - PERP Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human heart tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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PERP Rabbit anti-Human Polyclonal (aa162-191) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Select
PERP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
PERP Rabbit anti-Human Polyclonal (aa175-193) Antibody
Human
WB
Unconjugated
100 µg/$522
Select
PERP Rabbit anti-Human Polyclonal (aa37-50) Antibody
Human
WB
Unconjugated
100 µg/$403
PERP Antibody - PERP antibody Western blot of PANC1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PERP Rabbit anti-Human Polyclonal (aa107-156) Antibody
Human
WB
Unconjugated
100 µl/$424
PERP Antibody - PERP antibody Western blot of PANC1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PERP Rabbit anti-Human Polyclonal (aa107-156) (HRP) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
WB
HRP Conjugated
100 µl/$469
PERP Antibody - PERP antibody Western blot of PANC1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PERP Rabbit anti-Human Polyclonal (aa107-156) (Biotin) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
WB
Biotin Conjugated
100 µl/$469
PERP Antibody - PERP antibody Western blot of PANC1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PERP Rabbit anti-Human Polyclonal (aa107-156) (FITC) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
WB
FITC Conjugated
100 µl/$469
PERP Antibody - Western blot analysis of extracts of various cell lines, using PERP antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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PERP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PERP Protein - 12.5% SDS-PAGE of human PERP stained with Coomassie Blue
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Wheat Germ Extract
GST
47.8 kDa
10 µg/$479; 25 µg/$670
PERP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
21.2 kDa
100 µg/$494
PERP Protein - Purified recombinant protein PERP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
21.2 kDa
20 µg/$1,107
PERP Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His-SUMO, N-terminus + Myc, C-terminus
100 µg/$1,801; 20 µg/$1,247
PERP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
21.2 kDa
20 µg/$150
Viewing 1-23 of 23 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).