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Anti-PELP1 Antibody (aa1000-1050) LS-C56964

Note: This antibody replaces LS-C74229

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $345
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular PELP1 Antibodies

Anti-PELP1 Antibody (aa1000-1050) LS-C56964
Rabbit Polyclonal to Human PELP1
Human, Mouse
Western blot, Immunoprecipitation
Unconjugated
Western blot Image
Anti-PELP1 Antibody (aa1000-1050) IHC-plus™ LS-B13977
Rabbit Polyclonal (IgG) to Human PELP1
Human, Mouse
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry - Paraffin Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human PELP1
Human, Mouse
Western blot, Immunoprecipitation
Unconjugated

Details

Human PELP1
Rabbit
Human, Mouse (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Affinity purified
Unmodified

Applications

  • Western blot (1:2500 - 1:10000)
  • Immunoprecipitation

Specificity and Use

PELP1 antibody was raised against synthetic peptide corresponding to an epitope within amino acid residues 1000-1050 of human MNAR (AAN41255.1).
aa1000-1050
Recognizes MNAR (modulator of non-genomic activity of estrogen receptor), otherwise known as PELP1 (proline-, glutamic acid-, and leucine-rich protein-1), a phosphoprotein and novel steroid co-activator of the estrogen receptor (ER), which plays a role in E2-mediated cell cycle progression through interaction with the pRb pathway. MNAR acts as a transcriptional corepressor for nuclear receptors and can interact with chromatin-modifying complex components CBP (CRE-binding protein), histone deacetylase 2 and MTA (metastasis-associated protein)1. MNAR is a src SH2-binding protein which modulates the interaction of the ER to c-Src, leading to MAPK activation. Other properties of MNAR include interaction with PI3K, STAT3, and EGF, and studies have shown the deregulation of MNAR in breast tumors and endometrial cancers.
Western Blot: LS-C56964 detects a band of approximately 160-170kD in HeLa whole cell lysates.

Packaging

Tris-citrate/Phosphate buffered saline, 0.09% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About PELP1

Q8IZL8 BC002875 AAH02875.2

PELP1 Antibody, MNAR Antibody, Transcription factor HMX3 Antibody, p160 Antibody

Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1.

Western blot

Western blot
Detection of human MNAR in whole cell lysates from HeLa cells by immunoprecipitation using 3 ug/mg lysate of Rabbit anti-Human MNAR (LS-C56964). MNAR was also immunoprecipitated with an antibody recognizing a different region within human MNAR. Human MNAR was also detected by Western Blotting in whole cell lysates of HeLa and 293T cells using Rabbit anti-Human MNAR (LS-C56964).
 

Requested From: United States
Date Requested: 12/6/2016

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