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Anti-PDK2 Antibody (aa378-407) LS-C98957

Ordering

Wt. Vol. Conc. Price
- 400 µl - Unavailable

Related Products

70 PDK2 Antibodies

Most Popular PDK2 Antibodies

Anti-PDK2 Antibody (clone 2G1) IHC-plus™ LS-B5412
Mouse Monoclonal [clone 2G1] (IgG2a,k) to Human PDK2
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-PDK2 Antibody (clone 5F8) IHC-plus™ LS-B5413
Mouse Monoclonal [clone 5F8] (IgG2a,k) to Human PDK2
Human
IHC - Paraffin, Western blot, ELISA
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Immunohistochemistry Image
Anti-PDK2 Antibody (aa251-300) IHC-plus™ LS-B5583
Rabbit Polyclonal (IgG) to Human PDK2
Human, Bovine
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-PDK2 Antibody (aa78-107) LS-C164523
Rabbit Polyclonal to Mouse PDK2
Mouse, Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-PDK2 Antibody (aa379-392) LS-C313126
Rabbit Polyclonal (IgG) to Human PDK2
Human, Monkey, Mouse, Rat, Bat, Bovine, Guinea pig, Horse, Pig, Sheep
IHC - Paraffin, ICC, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (4)
Rabbit Polyclonal to Human PDK2
Human, Mouse, Rat, Primate
IHC - Paraffin, Western blot
Unconjugated

Details

Human PDK2
Rabbit
Human, Mouse, Rat, Primate (tested or 100% immunogen sequence identity)
Monkey, Mouse, Rat (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Ammonium sulfate precipitation
Unmodified

Applications

  • IHC - Paraffin (1:50 - 1:100)
  • Western blot (1:1000)

  • IHC - Paraffin

Specificity and Use

LS-E8630 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C98957. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
aa378-407
This PDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-407 amino acids from the C-terminal region of human PDK2.

Packaging

PBS, 0.09% sodium azide
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
For research use only.

Publications (4)

1
Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA. The Journal of biological chemistry. 2006 281:39897-906. (WB, ChrIP; Rat) [PubMed:17079227]
2
Regulation of pyruvate dehydrogenase in the common killifish, Fundulus heteroclitus, during hypoxia exposure. Richards JG, Sardella BA, Schulte PM. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 295:R979-90. [PubMed:18579651]
3
Effects of environmental hypoxia on cardiac energy metabolism and performance in tilapia. Speers-Roesch B, Sandblom E, Lau GY, Farrell AP, Richards JG. American journal of physiology. Regulatory, integrative and comparative physiology. 2010 298:R104-19. [PubMed:19864337]
4
The relationship between human skeletal muscle pyruvate dehydrogenase phosphatase activity and muscle aerobic capacity. Love LK, LeBlanc PJ, Inglis JG, Bradley NS, Choptiany J, Heigenhauser GJ, Peters SJ. Journal of applied physiology (Bethesda, Md. : 1985). 2011 111:427-34. [PubMed:21596918]
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About PDK2

Q15119 NM_002611 NP_002602.2

PDK2 Antibody, PDHK2 Antibody, PDHKII Antibody

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism.

Immunohistochemistry

Immunohistochemistry
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Western blot

Western blot
Western blot of PDK2 Antibody in mouse intestine tissue lysate (35 ug/lane). PDK2 (arrow) was detected using the purified antibody.

Western blot

Western blot
PDK2 Antibody (C392) western blot of HeLa cell line lysates (35 ug/lane). The PDK2 antibody detected the PDK2 protein (arrow).

Western blot

Western blot
Western blot of PDK2 (arrow) using PDK2 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PDK2 gene (Lane 2) (Origene Technologies).

Requested From: 
Date Requested: 4/27/2017

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