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PDK1
pyruvate dehydrogenase kinase, isozyme 1
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
| Gene Name: | pyruvate dehydrogenase kinase, isozyme 1 |
| Family/Subfamily: | Protein Kinase , PDK/BCKDK |
| Synonyms: | PDK1, PDHK, PDH kinase 1, PDHK1 |
| Target Sequences: | NM_002610 NP_002601.1 Q15118 |
Publications (3)
1
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL. Cell. 2011 145:732-44. (WB, ChrIP; Human)
[PubMed:21620138]
[PMC:PMC3130564]
2
Caffeic acid phenethyl ester causes p21 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells. Lin HP, Jiang SS, Chuu CP. PloS one. 2012 7:e31286.
[PubMed:22347457]
[PMC:PMC3274546]
3
Enhanced glucose metabolism through activation of HIF-1a covers the energy demand in a rat embryonic heart primordium after heartbeat initiation. Tatsuya Sato , Nobutoshi Ichise , Takeshi Kobayashi, Hiroyori Fusagawa, Hiroya Yamazaki, Taiki Kudo, Noritsugu Tohse. Scientific reports. 2022 January;12:74. [Full Text Article]
[PubMed:34996938]
[PMC:PMC8741773]
Related Antibodies: LS-B1733.
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PDK1 Rabbit anti-Human Polyclonal (aa350-436) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
PDK1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
PDK1 Rabbit anti-Human Polyclonal (C-Terminus) (DY650) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
PDK1 Rabbit anti-Human Polyclonal (C-Terminus) (DY488) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
PDK1 Rabbit anti-Human Polyclonal (C-Terminus) (DY550) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
PDK1 Rabbit anti-Human Polyclonal (aa421-436) Antibody
Mouse, Dog, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$529; 200 µg/$854
PDK1 Rabbit anti-Human Polyclonal (aa300-400) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
PDK1 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody
Human
IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
PDK1 Rabbit anti-Human Polyclonal (Internal) (DY650) Antibody
Mouse, Human
IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
PDK1 Rabbit anti-Human Polyclonal (Internal) (DY488) Antibody
Mouse, Human
IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
PDK1 Rabbit anti-Human Polyclonal (Internal) (DY550) Antibody
Mouse, Human
IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
PDK1 Mouse anti-Human Monoclonal (4A11) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PDK1 Rabbit anti-Human Polyclonal Antibody
Rabbit, Mouse, Dog, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$485
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PDK1 Mouse anti-Human Monoclonal (4A11) Antibody
Mouse, Rat, Non-Human Primate, Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µl/$541
PDK1 Mouse anti-Human Monoclonal Antibody
Rat, Human, Monkey
ELISA, Flo, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
PDK1 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
IP, WB
Unconjugated
20 µl/$453; 100 µl/$643
PDK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
PDK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
PDK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PDK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
PDK1 Rabbit anti-Human Polyclonal (aa408-421) Antibody
Rabbit, Guinea pig, Sheep, Bovine, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PDK1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100 µl/$332
PDK1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC
Unconjugated
100 µl/$332
PDK1 Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) Antibody
Mouse, Human
ELISA, WB
Unconjugated, Azide-free
200 µl/$734
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