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Human PDI / P4HB | |
Mouse | |
Human (tested or 100% immunogen sequence identity) | |
IgG1,k Monoclonal [3-2B12] | |
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE. | |
Purified | |
Unmodified |
PDI / P4HB antibody was raised against human prolyl 4-hydroxylase (hPH). | |
Recognizes the b-subunit of human Prolyl Hydroxylase, 4. | |
Immunohistochemistry: LS-B2162 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2162 was determined to be 2.5 ug/ml. |
PBS, pH 7.0, 2% BSA (protease free). | |
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles. | |
For research use only. |
P4HB Antibody, ERBA2L Antibody, DSI Antibody, GIT Antibody, p4HB Antibody, p4Hbeta Antibody, PDIA1 Antibody, PHDB Antibody, PO4DB Antibody, PROHB Antibody, Protocollagen hydroxylase Antibody, Protein disulfide-isomerase Antibody, PO4HB Antibody, PDI Antibody
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins.
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