PDHX / Protein X / ProX

pyruvate dehydrogenase complex, component X

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Products

Antibodies (26)

Proteins (12)

ELISA Kits (1)

Type

Over-Expression Lysate (6)

Primary (26)

Recombinant (6)

Sandwich (1)

Target

PDHX / Protein X / ProX (39)

Reactivity

Human (19)

Mouse (11)

Rat (3)

Monkey (2)

Pig (8)

Application

IHC (7)

IHC-P (3)

WB (26)

ELISA (3)

ICC (1)

IF (4)

IP (1)

Peptide-ELISA (2)

Host

rabbit (24)

mouse (1)

goat (1)

Product Group

IHCPlus (1)

Isotype

IgG (5)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (25)

Clone

AT1E11 (1)

Format

96-Well Strip Plate (1)

APC (2)

APC Conjugated (2)

Biotin Conjugated (2)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (12)

Epitope

aa220-468 (8)

aa222-471 (8)

Thr11 (1)

aa1-300 (1)

aa429-459 (1)

aa488-501 (1)

Publications

No (39)

Sample Type

Cell Lysates (1)

Tissue Homogenates (1)

Tag

6His-SUMO, N-terminus (1)

GST, N-terminus (1)

His (1)

His-T7 (2)

Myc-DDK (Flag) (7)

Species

Hepatitis B Virus (1)

Human (7)

Mouse (1)

Source

293T Cells (3)

E. coli (4)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (2)

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IHC-plus™ PDHX / Protein X / ProX Antibody (Thr11) LS-B9012

(4.0) Rating

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (Thr11) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$440

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PDHX / Protein X / ProX Antibody (aa1-300) LS-C376290

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa1-300) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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PDHX / Protein X / ProX Antibody LS-C667563

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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PDHX / Protein X / ProX Antibody LS-C334709

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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PDHX / Protein X / ProX Antibody LS-C482606

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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PDHX / Protein X / ProX Antibody (aa429-459) LS-C97695

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa429-459) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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PDHX / Protein X / ProX Antibody LS-C802941

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PDHX / Protein X / ProX Antibody (aa488-501) LS-C20201

Antibody:

PDHX / Protein X / ProX Goat anti-Human Polyclonal (aa488-501) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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PDHX / Protein X / ProX Antibody LS-C768948

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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PDHX / Protein X / ProX Antibody (clone AT1E11) LS-C755529

Antibody:

PDHX / Protein X / ProX Mouse anti-Human Monoclonal (AT1E11) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$303; 100 µl/$365

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PDHX / Protein X / ProX Antibody (aa222-471) LS-C374914

Antibody:

PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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PDHX / Protein X / ProX Antibody (aa222-471, HRP) LS-C713916

Antibody:

PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (HRP) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639

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PDHX / Protein X / ProX Antibody (aa222-471, Biotin) LS-C688971

Antibody:

PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

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PDHX / Protein X / ProX Antibody (aa222-471, FITC) LS-C696014

Antibody:

PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

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PDHX / Protein X / ProX Antibody (aa222-471, APC, Cy7) LS-C736895

Antibody:

PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (APC, Cy7) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781

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PDHX / Protein X / ProX Antibody (aa222-471, Cy3) LS-C704903

Antibody:

PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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PDHX / Protein X / ProX Antibody (aa222-471, PE) LS-C727985

Antibody:

PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

Select

PDHX / Protein X / ProX Antibody (aa222-471, APC) LS-C719088

Antibody:

PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (APC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

• Unconjugated
• HRP
• Biotin
• FITC
• APC, Cy7
• Cy3
• PE
• More...
  • APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC, Cy7
  • Cy3
  • PE
  • APC

Select

PDHX / Protein X / ProX Antibody (aa220-468) LS-C374911

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

Select

PDHX / Protein X / ProX Antibody (aa220-468, HRP) LS-C713912

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (HRP) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593

Select

PDHX / Protein X / ProX Antibody (aa220-468, Biotin) LS-C688972

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (Biotin) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

Select

PDHX / Protein X / ProX Antibody (aa220-468, FITC) LS-C696012

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (FITC) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716

Select

PDHX / Protein X / ProX Antibody (aa220-468, APC, Cy7) LS-C736894

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (APC, Cy7) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676

Select

PDHX / Protein X / ProX Antibody (aa220-468, Cy3) LS-C704902

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (Cy3) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

Select

PDHX / Protein X / ProX Antibody (aa220-468, PE) LS-C727984

Antibody:

PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (PE) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

• Unconjugated
• HRP
• Biotin
• FITC
• APC, Cy7
• Cy3
• PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC, Cy7
  • Cy3
  • PE

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