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PDHA1 / PDH E1 Alpha
pyruvate dehydrogenase (lipoamide) alpha 1
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | pyruvate dehydrogenase (lipoamide) alpha 1 |
| Synonyms: | PDHA1, PDHCE1A, PDHA, PHE1A, PDHE1-A type I |
| Target Sequences: | NM_000284 NP_000275.1 P08559 |
Publications (8)
1
Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. McFate T, Mohyeldin A, Lu H, Thakar J, Henriques J, Halim ND, Wu H, Schell MJ, Tsang TM, Teahan O, Zhou S, Califano JA, Jeoung NH, Harris RA, Verma A. The Journal of biological chemistry. 2008 283:22700-8.
[PubMed:18541534]
[PMC:PMC2504897]
2
Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. Acin-Perez R, Hoyos B, Zhao F, Vinogradov V, Fischman DA, Harris RA, Leitges M, Wongsiriroj N, Blaner WS, Manfredi G, Hammerling U. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 24:627-36.
[PubMed:19812372]
[PMC:PMC2812036]
3
Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria. Acin-Perez R, Hoyos B, Gong J, Vinogradov V, Fischman DA, Leitges M, Borhan B, Starkov A, Manfredi G, Hammerling U. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 24:5033-42. (WB; Mouse)
[PubMed:20798245]
[PMC:PMC2992363]
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PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal (aa39-325) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PDHA1 / PDH E1 Alpha Mouse anti-Human Monoclonal (OTI2C10) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
PDHA1 / PDH E1 Alpha Mouse anti-Human Monoclonal (Carrier-free) (OTI2C10) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
![PDHA1 / PDH E1 Alpha Antibody - Pyruvate Dehydrogenase E1-alpha subunit [phospho Ser293] Antibody - Detection of PDHE1 (Green) in HepG2 cells. Nuclei (Blue) are counterstained with Hoechst 33248. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/pdha1-pdh-e1-alpha-antibody-phospho-ser293-ls-c141917/59715_4963203.jpg)
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal (pSer293) Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
0.05 ml/$386
![PDHA1 / PDH E1 Alpha Antibody - Pyruvate Dehydrogenase E1-alpha subunit [phospho Ser293] Antibody - Detection of PDHE1 (Green) in HepG2 cells. Nuclei (Blue) are counterstained with Hoechst 33248. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/pdha1-pdh-e1-alpha-antibody-phospho-ser293-biotin-ls-c141918/59715_4963203.jpg)
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal (pSer293) (Biotin) Antibody
Mouse, Rat, Human
ICC, IF, WB
Biotin Conjugated
0.05 ml/$416
![PDHA1 / PDH E1 Alpha Antibody - Pyruvate Dehydrogenase E1-alpha subunit [phospho Ser293] Antibody - Detection of PDHE1 (Green) in HepG2 cells. Nuclei (Blue) are counterstained with Hoechst 33248. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/pdha1-pdh-e1-alpha-antibody-phospho-ser293-dy650-ls-c141919/59715_4963203.jpg)
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal (pSer293) (DY650) Antibody
Human
ICC, IF, WB
DY650 Conjugated
0.05 ml/$416
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal (aa228-255) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
PDHA1 / PDH E1 Alpha Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$371
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Pig, Rat, Mouse, Bovine, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$397
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PDHA1 / PDH E1 Alpha Mouse anti-Human Monoclonal (OTI2B10) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
PDHA1 / PDH E1 Alpha Mouse anti-Human Monoclonal (Carrier-free) (OTI2B10) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
E. coli
His
41.7 kDa
10 µg/$281; 50 µg/$442; 100 µg/$707; 200 µg/$885; 1 mg/$1,994; 500 µg/$1,534; 5 mg/$3,095; 2 mg/$2,181
Wheat Germ Extract
GST
68.64 kDa
10 µg/$479; 25 µg/$670
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal (pSer293) Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$649
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$334; 100 µl/$397
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal (aa228-255) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal (290-370 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
PDHA1 / PDH E1 Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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