Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG2b) to Human PDGFRB / PDGFR Beta
Western blot, Immunoprecipitation, ELISA
Human PDGFRB / PDGFR Beta
Human, Mouse (tested or 100% immunogen sequence identity)
Western blot (1:1000)
Specificity and Use
Synthetic phosphopeptide corresponding to residues surrounding Tyr751 of human PDGF receptor beta (KLH coupled).
Detects endogenous levels of human PDGF receptor beta (190kD) only when phosphorylated at Tyr751. Does not cross-react with other tyrosine-phosphorylated proteins. Species cross-reactivity: mouse. Species sequence homology: rat.
Suitable for use in Western Blot, Immunoprecipitation and ELISA. Western Blot: 1:1000. Immunoprecipitation: 1:100.
10 mM sodium HEPES, pH 7.5, 150 mM sodium chloride, 0.1 mg/ml BSA, 50% glycerol, 0.02% sodium azide.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.