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Anti-PDGFRA / PDGFR Alpha Antibody (Extracellular Domain, clone 35248 (57/20)) LS-C11204

Note: This antibody replaces LS-C122319

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $390
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular PDGFRA / PDGFR Alpha Antibodies

Anti-PDGFRA / PDGFR Alpha Antibody (C-Terminus) IHC-plus™ LS-B2172
Rabbit Polyclonal to Human PDGFRA / PDGFR Alpha
Human, Mouse, Rat
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-PDGFRA / PDGFR Alpha Antibody (aa1035-1053) IHC-plus™ LS-B6056
Rabbit Polyclonal (IgG) to Human PDGFRA / PDGFR Alpha
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 35248 (57/20)] (IgG1) to Human PDGFRA / PDGFR Alpha
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated

Details

Human PDGFRA / PDGFR Alpha
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [35248 (57/20)]
Unconjugated
Protein G purified
Unmodified

Applications

  • IHC - Paraffin (10 - 20 µg/ml)
  • Western blot (1 - 2 µg/ml)
  • ELISA (0.5 - 1 µg/ml)

Specificity and Use

PDGFRA / PDGFR Alpha antibody was raised against purified recombinant human platelet-derived growth factor (PDGF) receptor alpha (extracellular domain), derived from the insect cell line Sf21.
Extracellular Domain
Recognizes the human platelet-derived growth factor receptor alpha, a 1089 amino acid, ~180 kD single pass type I transmembrane glycoprotein. PDGF is a major serum mitogen that can exist as a homo- or heterodimeric protein consisting of disulphide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Whereas PDGF receptor alpha binds all three isoforms with high affinity, PDGF R beta binds PDGF-BB and AB but not PDGF-AA. Both PDGF receptor alpha and beta are members of the class III subfamily of receptor tyrosine kinases. Has been reported for use in functional studies. The ND50 was determined as 0.2-0.6 Âug/ml for blocking 10 ng/ml of PDGF-AA biological activity on a quiescent confluent cell culture of human WS1 cells.

Packaging

PBS, 0.09% sodium azide, 1.5% Trehalose
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

About PDGFRA / PDGFR Alpha

P16234 NM_006206 NP_006197.1

PDGFRA Antibody, CD140A Antibody, CD140a antigen Antibody, PDGFalphaR Antibody, PDGFR2 Antibody, PDGFRalpha Antibody, AlphaPDGFR Antibody, RHEPDGFRA Antibody, PDGF receptor alpha Antibody, PDGFR-2 Antibody, PDGFRA/BCR fusion Antibody, APDGFR Antibody, Pdgf alpha-receptor Antibody, PDGF-R-alpha Antibody, PDGFR-alpha Antibody

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development.

Requested From: United States
Date Requested: 12/8/2016

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