Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 16A1] (IgG1) to Human PDGFRA / PDGFR Alpha
ICC, Flow Cytometry (applications tested for the base form of this product only)
Human PDGFRA / PDGFR Alpha
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [16A1]
Protein A purified
(applications tested for the base form of this product only)
IHC - Paraffin
Specificity and Use
PDGFRA / PDGFR Alpha antibody was raised against cD140a-transfected NIH 3T3 cells.
The mouse monoclonal antibody 16A1 recognizes CD140a / PDGF-RA, the 170 kD alpha chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumors. HLDA VI.; WS Code E022.
Flow Cytometry: Recommended dilution - 2 ug/ml.
PBS, 15 mM sodium azide, pH 7.4
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development.