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Anti-PDGF-BB Antibody LS-C42999

Ordering

Wt. Vol. Conc. Price
100 µg 100 µl 1 mg/ml $435
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular PDGF-BB Antibodies

Anti-PDGF-BB Antibody (aa222-233) IHC-plus™ LS-B4182
Goat Polyclonal to Human PDGF-BB
Human, Bovine, Sheep
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-PDGF-BB Antibody (N-Terminus) IHC-plus™ LS-B6945
Rabbit Polyclonal to Human PDGF-BB
Human, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Rabbit, Sheep, Xenopus
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-PDGF-BB Antibody (C-Terminus) LS-C201038
Rabbit Polyclonal to Human PDGF-BB
Human, Mouse, Rat
Immunofluorescence, Western blot, ELISA
Unconjugated
Immunofluorescence Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human PDGF-BB
Human
Western blot, ELISA, Functional Assay
Unconjugated

Details

Human PDGF-BB
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Purified
Unmodified

Applications

  • Western blot (0.1 - 0.2 µg/ml)
  • ELISA (0.5 µg/ml)
  • Functional Assay (3 - 4 µg/ml)

Specificity and Use

PDGF-BB antibody was raised against recombinant human PDGF-BB.
Recognizes human PDGF-BB (Platelet derived growth factor B chain), a disulphide-linked beta-chain homodimer and member of the PDGF family, released from platelet alpha-granules following trauma/platelet activation. Naturally occurring active forms of PDGF exist as dimers of two alpha chains (AA), two beta chains (BB), or a combination of both chains (AB), all of which signal through the high-affinity PDGF-Ralpha receptor, and the latter two of which can also signal through the PDGF-Rbeta receptor. PDGFs are potent mitogens for a variety of cells including those of the connective tissue, bone and cartilage, blood and smooth muscle cells, and are involved in several biological processes including chemotaxis, hyperplasia and embryonic neurogenesis. The expression of PDGF-BB is associated with autocrine growth stimulation and the formation of various tumor types, with several studies focusing on dermatofibrosarcoma protuberans (DP), an infiltrating skin tumor arising from a translocation occurring between chromosome 22 (the location of the PDGFB gene) and chromosome 17 (the location of the COL1A1 gene), which results in the generation of the COL1A1-PDGFB chimeric protein.

Packaging

Lyophilized, PBS, pH 7.4.
100 µl Distilled Water. For long term storage the addition of 0.09% sodium azide is recommended. For functional studies do not add azide.
For research use only.

About PDGF-BB

P01127 NM_002608 NP_002599.1

PDGFB Antibody, Becaplermin Antibody, PDGF-BB Antibody, PDGF-b Antibody, SSV Antibody, PDGF subunit B Antibody, PDGF-2 Antibody, PDGF2 Antibody, Proto-oncogene c-Sis Antibody, SIS Antibody, C-sis Antibody, PDGF, B chain Antibody

PDGF-BB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

Requested From: United States
Date Requested: 12/7/2016

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