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Anti-PDE4D Antibody (phospho-Ser190/Ser53) LS-C199417

Catalog	Size	Price
LS-C199417-50	50 µl	Unavailable
LS-C199417-100	100 µl	Unavailable

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Antibody:	Rabbit Polyclonal (IgG) to Human PDE4D
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Format:	Unconjugated

IHC of paraffin-embedded human colon carcinoma, using PDE4D (Phospho-Ser190/53) Antibody. The sample on the right was incubated with synthetic peptide.

Western blot of extracts from K562 cells treated with H2O2 100uM 30', using PDE4D (Phospho-Ser190/53) Antibody. The lane on the right was incubated with synthetic peptide.

Details

Target:	Human PDE4D
Host:	Rabbit
Reactivity:	Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality:	IgG Polyclonal
Conjugations:	Unconjugated
Purification:	Immunoaffinity purified
Modifications:	Unmodified

Applications

Approved:

IHC
IHC - Paraffin (1:50 - 1:100)
Western blot (1:500 - 1:1000)
ELISA (1:20000)

Specificity and Use

Immunogen:	PDE4D antibody was raised against synthetic peptide derived from human PDE4D around the phosphorylation site of Ser190/53.
Epitope:	pSer190/Ser53
Specificity:	PDE4D (Phospho-Ser190/53) Antibody detects endogenous levels of PDE4D only when phosphorylated at serine190/53.

Packaging

Presentation:	PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Storage:	Store at -20°C.
Restrictions:	For research use only.

About PDE4D

Uniprot: Q08499 NCBI: NM_006203 NP_006194.2

Synonyms: PDE4D Antibody, ACRDYS2 Antibody, DPDE3 Antibody, HSPDE4D Antibody, PDE43 Antibody, Pde-ivd Antibody, PDE4DN2 Antibody, Phosphodiesterase 4d Antibody, STRK1 Antibody

Description: Phosphodiesterase 4D, a cAMP-specific phosphodiesterase, has been shown to affect growth and fertility, functioning of pro-inflammatory immune cells, and cholinergic stimulation of the airway and consequently the development of hyperreactive disease states such as asthma. PDE4D activity is inhibited by rolipram. At least six splice variants have been reported.

(More About PDE4D)

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Immunohistochemistry

IHC of paraffin-embedded human colon carcinoma, using PDE4D (Phospho-Ser190/53) Antibody. The sample on the right was incubated with synthetic peptide.

Western blot

Western blot of extracts from K562 cells treated with H2O2 100uM 30', using PDE4D (Phospho-Ser190/53) Antibody. The lane on the right was incubated with synthetic peptide.

Requested From:
Date Requested: 4/23/2018

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