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PDCD1 / CD279 / PD-1

programmed cell death 1

PDCD1 / CD279 / PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Gene Name:	programmed cell death 1
Family/Subfamily:	Apoptosis
Synonyms:	PDCD1, CD279, HPD-1, HPD-l, PD1, Protein PD-1, SLEB2, PD-1, CD279 antigen, Programmed cell death 1
Target Sequences:	NM_005018 NP_005009.2 Q15116

Publications (9)

Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm. Zahn RC, Rett MD, Korioth-Schmitz B, Sun Y, Buzby AP, Goldstein S, Brown CR, Byrum RA, Freeman GJ, Letvin NL, Hirsch VM, Schmitz JE. Journal of virology. 2008 82:11577-88. [PubMed:18829748] [PMC:PMC2583661] Related Antibodies: LS-C40800.

Cutting edge: Programmed death-1/programmed death ligand 1 interaction regulates the induction and maintenance of invariant NKT cell anergy. Chang WS, Kim JY, Kim YJ, Kim YS, Lee JM, Azuma M, Yagita H, Kang CY. Journal of immunology (Baltimore, Md. : 1950). 2008 181:6707-10. [PubMed:18981087] Related Antibodies: LS-C40800.

Human immunodeficiency virus type 1 escapes from interleukin-2-producing CD4+ T-cell responses without high-frequency fixation of mutations. Jones RB, Yue FY, Gu XX, Hunter DV, Mujib S, Gyenes G, Mason RD, Mohamed R, MacDonald KS, Kovacs C, Ostrowski MA. Journal of virology. 2009 83:8722-32. [PubMed:19553327] [PMC:PMC2738181] Related Antibodies: LS-C40800.

Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic. Vojnov L, Reed JS, Weisgrau KL, Rakasz EG, Loffredo JT, Piaskowski SM, Sacha JB, Kolar HL, Wilson NA, Johnson RP, Watkins DI. Journal of virology. 2010 84:753-64. [PubMed:19889785] [PMC:PMC2798340] Related Antibodies: LS-C40800.

Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling. Radziewicz H, Ibegbu CC, Hon H, Bdard N, Bruneau J, Workowski KA, Knechtle SJ, Kirk AD, Larsen CP, Shoukry NH, Grakoui A. Journal of immunology (Baltimore, Md. : 1950). 2010 184:2410-22. [PubMed:20100932] [PMC:PMC2924663] Related Antibodies: LS-C40800.

Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin 7. Monteiro P, Gosselin A, Wacleche VS, El-Far M, Said EA, Kared H, Grandvaux N, Boulassel MR, Routy JP, Ancuta P. Journal of immunology (Baltimore, Md. : 1950). 2011 186:4618-30. [PubMed:21398606] Related Antibodies: LS-C40800.

Dominant clonotypes within HIV-specific T cell responses are programmed death-1high and CD127low and display reduced variant cross-reactivity. Conrad JA, Ramalingam RK, Smith RM, Barnett L, Lorey SL, Wei J, Simons BC, Sadagopal S, Meyer-Olson D, Kalams SA. Journal of immunology (Baltimore, Md. : 1950). 2011 186:6871-85. [PubMed:21562156] [PMC:PMC3403726] Related Antibodies: LS-C40800.

Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma. Matias Autio, Suvi-Katri Leivonen, Oscar Brück, Satu Mustjoki, Judit Mészáros Jørgensen, Marja-Liisa Karjalainen-Lindsberg, Klaus Beiske, Harald Holte, Teijo Pellinen, Sirpa Leppä. Haematologica. 2020 February; [Full Text Article] [PubMed:32079690] [PMC:PMC7927991] Related Antibodies: LS-B12784.

Somatic Mutations and Immune Alternation in Rectal Cancer Following Neoadjuvant Chemoradiotherapy. Dengbo Ji , Haizhao Yi , Dakui Zhang , Tiancheng Zhan, Zhaowei Li, Ming Li, Jinying Jia, Meng Qiao, Jinhong Xia, Zhiwei Zhai, Can Song, Jin Gu. Cancer immunology research. 2018 Nov;6:1401-1416. [Full Text Article] [PubMed:30282671] Related Antibodies: LS-B540.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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