Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone MIH4] (IgG1) to Human PDCD1 / CD279 / PD-1
Human PDCD1 / CD279 / PD-1
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MIH4]
Protein G purified
Specificity and Use
Human CD279 - transfected ul cells.
Recognizes human CD279.
Suitable for use in Flow cytometry. Flow Cytometry: Neat Use 10 ul of the suggested working dilution to label 1x1E6 cells in 100ul. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Lyophilized powder from PBS, pH 7.4, 0.09% sodium azide, 1% BSA. Reconstitute, 1 ml ddH2O, 40-50% glycerol.
PDCD1 / CD279 / PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure.