PCSK9

proprotein convertase subtilisin/kexin type 9

Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na+ channel (ENaC)-mediated Na+ absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.

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Products

Antibodies (82)

ELISA Kits (30)

Proteins (22)

Type

Custom (1)

Over-Expression Lysate (2)

Primary (82)

Recombinant (20)

Sandwich (27)

Sandwich CLIA (2)

Target

PCSK9 (134)

Reactivity

Human (62)

Mouse (26)

Rat (24)

Chicken (1)

Guinea pig (2)

Hamster (1)

Monkey (4)

Porcine (1)

Rabbit (3)

Sheep (1)

Application

IHC (16)

IHC-P (8)

WB (62)

Flo (8)

ELISA (28)

Func (1)

ICC (7)

IF (4)

IP (1)

Peptide-ELISA (4)

Host

rabbit (67)

mouse (12)

goat (3)

Product Group

IHCPlus (2)

Isotype

IgG (27)

IgG1 (8)

Clonality

monoclonal mc (15)

polyclonal pc (67)

Clone

007 (1)

03 (1)

06 (1)

15 (1)

20 (1)

214 (1)

4F10H8B2 (1)

A1 (1)

OTI4G9 (2)

OTI8C12 (2)

OTI8E10 (2)

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Format

12 x 8-Well Microstrips (3)

96-Well Microplate (7)

96-Well Strip Plate (19)

APC (4)

APC Conjugated (5)

Azide-free (1)

Biotin Conjugated (5)

Carrier-free (3)

Cy3 Conjugated (4)

Cy7 Conjugated (4)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (5)

Preservative Free (11)

Unconjugated (49)

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Epitope

aa156-461 (8)

aa156-694 (8)

aa164-428 (8)

aa454-679 (8)

aa144-173 (7)

aa153-692 (6)

Internal (1)

aa164-175 (1)

aa214-228 (1)

aa450-500 (1)

aa479-508 (1)

aa490-502 (1)

aa654-688 (1)

aa671-687 (1)

aa679-692 (1)

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Publications

No (134)

Sample Type

Cell Culture Supernatants (7)

EDTA Plasma (1)

Heparin Plasma (1)

Plasma (25)

Serum (26)

Tissue Homogenates (9)

Tag

6His, C-terminus (7)

6His-HA-AVI, C-terminus (1)

AVI, C-terminus (1)

DDK (Flag)-His, C-terminus (1)

GST (1)

His (3)

His,C-terminus (2)

His-GST (1)

His-GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (13)

Mouse (4)

Rat (2)

Southern pig-tailed macaque (2)

Source

293T Cells (1)

CHO Cells (1)

E. coli (4)

HEK 293 Cells (4)

Human Cells (5)

Mammalian Cells (6)

Wheat Germ Extract (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (13)

Biologically Active

Biologically active (1)

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IHC-plus™ PCSK9 Antibody LS-B6939

(4.0) Rating

Antibody:

PCSK9 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

250 µl/$460

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PCSK9 Antibody (aa454-679) LS-B13940

Antibody:

PCSK9 Rabbit anti-Human Polyclonal (aa454-679) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$460

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PCSK9 Antibody (aa144-173, Biotin) LS-C281246

Antibody:

PCSK9 Rabbit anti-Human Polyclonal (aa144-173) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

PCSK9 Antibody (aa144-173, FITC) LS-C281247

Antibody:

PCSK9 Rabbit anti-Human Polyclonal (aa144-173) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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PCSK9 Antibody (aa144-173, Azide-free, HRP) LS-C281248

Antibody:

PCSK9 Rabbit anti-Human Polyclonal (aa144-173) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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PCSK9 Antibody (aa144-173, PE) LS-C281249

Antibody:

PCSK9 Rabbit anti-Human Polyclonal (aa144-173) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Biotin
• FITC
• HRP, Azide-free
• PE

• Biotin
• FITC
• HRP, Azide-free
• More...
  • PE

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PCSK9 Antibody LS-C146648

Antibody:

PCSK9 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

1 Each/$449

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PCSK9 Antibody (aa214-228) LS-C139568

Antibody:

PCSK9 Goat anti-Human Polyclonal (aa214-228) Antibody

Reactivity:

Mouse, Rat, Hamster, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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PCSK9 Antibody (aa156-461, Biotin) LS-C423462

Antibody:

PCSK9 Rabbit anti-Human Polyclonal (aa156-461) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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PCSK9 Antibody (aa671-687) LS-C313516

Antibody:

PCSK9 Rabbit anti-Human Polyclonal (aa671-687) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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Monkey PCSK9 (Sandwich ELISA) ELISA Kit - LS-F47169

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$863

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Monkey PCSK9 (Sandwich ELISA) ELISA Kit - LS-F50828

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

1.1 - 800 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$1,041

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Rat PCSK9 (Sandwich ELISA) ELISA Kit - LS-F22819

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$771

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Porcine PCSK9 (Sandwich ELISA) ELISA Kit - LS-F38573

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$863

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Rat PCSK9 (Sandwich ELISA) ELISA Kit - LS-F9168

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$893

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PCSK9 Antibody (aa679-692) LS-C55246

Antibody:

PCSK9 Goat anti-Human Polyclonal (aa679-692) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

PCSK9 Antibody LS-C146687

Antibody:

PCSK9 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

1 Each/$431

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PCSK9 Antibody (aa479-508) LS-C100922

Antibody:

PCSK9 Rabbit anti-Human Polyclonal (aa479-508) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Mouse PCSK9 (Sandwich ELISA) ELISA Kit - LS-F23851

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Rat PCSK9 Protein (Recombinant His-GST, N-terminus) (Trp164-Phe428) - LS-G25431

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

58.1 kDa

Price:

10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329

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Mouse PCSK9 (Sandwich ELISA) ELISA Kit - LS-F35061

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human PCSK9 (Sandwich ELISA) ELISA Kit - LS-F717

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$618

Select

PCSK9 Antibody (aa454-679, Biotin) LS-C300206

Antibody:

PCSK9 Rabbit anti-Human Polyclonal (aa454-679) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

Select

PCSK9 Antibody LS-C140637

Antibody:

PCSK9 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$466

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PCSK9 Antibody (clone 20, Preservative Free) LS-C820137

Antibody:

PCSK9 Mouse anti-Human Monoclonal (Preservative Free) (20) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

20 µl/$256; 100 µl/$412

Viewing 1-25 of 134 product results

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