PCSK1

proprotein convertase subtilisin/kexin type 1

PCSK1 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene

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Products

Antibodies (36)

Proteins (7)

ELISA Kits (2)

Type

Over-Expression Lysate (2)

Primary (36)

Recombinant (5)

Sandwich (2)

Target

PCSK1 (45)

Reactivity

Human (21)

Mouse (12)

Rat (15)

Bat (1)

Bovine (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (4)

Horse (4)

Monkey (4)

Orangutan (3)

Pig (9)

Rabbit (1)

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Application

IHC (6)

IHC-P (6)

WB (27)

Flo (1)

ELISA (10)

IF (2)

Host

rabbit (35)

mouse (1)

Product Group

IHCPlus (2)

Isotype

Ig (2)

IgG (10)

IgG3,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (35)

Clone

3D2 (1)

Format

96-Well Strip Plate (2)

APC (2)

APC Conjugated (2)

Biotin Conjugated (5)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (2)

Unconjugated (13)

Epitope

aa244-530 (8)

aa500-738 (8)

aa683-732 (4)

C-Terminus (1)

N-Terminus (1)

aa726-740 (1)

Publications

No (45)

Sample Type

Plasma (2)

Serum (2)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His (1)

His-T7 (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Human Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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IHC-plus™ PCSK1 Antibody (clone 3D2) LS-B5411

(4.0) Rating

Antibody:

PCSK1 Mouse anti-Human Monoclonal (3D2) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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PCSK1 Antibody (C-Terminus) LS-C757752

Antibody:

PCSK1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, Flo, IF, WB

Format:

Unconjugated

Price:

200 µl/$393

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PCSK1 Antibody (aa683-732) LS-B6536

Antibody:

PCSK1 Rabbit anti-Human Polyclonal (aa683-732) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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PCSK1 Antibody (aa683-732, HRP) LS-C430232

Antibody:

PCSK1 Rabbit anti-Human Polyclonal (aa683-732) (HRP) Antibody

Reactivity:

Dog, Guinea pig, Bovine, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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PCSK1 Antibody (aa683-732, Biotin) LS-C430231

Antibody:

PCSK1 Rabbit anti-Human Polyclonal (aa683-732) (Biotin) Antibody

Reactivity:

Dog, Guinea pig, Bovine, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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PCSK1 Antibody (aa683-732, FITC) LS-C430233

Antibody:

PCSK1 Rabbit anti-Human Polyclonal (aa683-732) (FITC) Antibody

Reactivity:

Dog, Guinea pig, Bovine, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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PCSK1 Antibody (N-Terminus) LS-C757749

Antibody:

PCSK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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Human PCSK1 (Sandwich ELISA) ELISA Kit - LS-F6711

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$834

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PCSK1 Antibody (aa726-740) LS-C313202

Antibody:

PCSK1 Rabbit anti-Human Polyclonal (aa726-740) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Rat, Pig, Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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PCSK1 Antibody (aa244-530) LS-C374796

Antibody:

PCSK1 Rabbit anti-Mouse Polyclonal (aa244-530) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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PCSK1 Antibody (aa244-530, HRP) LS-C712946

Antibody:

PCSK1 Rabbit anti-Mouse Polyclonal (aa244-530) (HRP) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639

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PCSK1 Antibody (aa244-530, Biotin) LS-C688259

Antibody:

PCSK1 Rabbit anti-Mouse Polyclonal (aa244-530) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

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PCSK1 Antibody (aa244-530, FITC) LS-C695187

Antibody:

PCSK1 Rabbit anti-Mouse Polyclonal (aa244-530) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

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PCSK1 Antibody (aa244-530, APC) LS-C718528

Antibody:

PCSK1 Rabbit anti-Mouse Polyclonal (aa244-530) (APC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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PCSK1 Antibody (aa244-530, PE) LS-C727009

Antibody:

PCSK1 Rabbit anti-Mouse Polyclonal (aa244-530) (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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PCSK1 Antibody (aa244-530, Cy3) LS-C703927

Antibody:

PCSK1 Rabbit anti-Mouse Polyclonal (aa244-530) (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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PCSK1 Antibody (aa244-530, APC, Cy7) LS-C735934

Antibody:

PCSK1 Rabbit anti-Mouse Polyclonal (aa244-530) (APC, Cy7) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE
• Cy3
• More...
  • APC, Cy7

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE
  • Cy3
  • APC, Cy7

Select

PCSK1 Antibody LS-C670782

Antibody:

PCSK1 Rabbit anti-Rat Polyclonal Antibody

Reactivity:

Rat

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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PCSK1 Antibody LS-C488657

Antibody:

PCSK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

Select

PCSK1 Antibody LS-C488656

Antibody:

PCSK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

Select

PCSK1 Antibody LS-C747390

Antibody:

PCSK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

PCSK1 Antibody LS-C816928

Antibody:

PCSK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$317; 100 µl/$375; 200 µl/$473

Select

PCSK1 Antibody (aa500-738) LS-C373241

Antibody:

PCSK1 Rabbit anti-Human Polyclonal (aa500-738) Antibody

Reactivity:

Mouse, Rat, Pig, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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PCSK1 Antibody (aa500-738, HRP) LS-C712949

Antibody:

PCSK1 Rabbit anti-Human Polyclonal (aa500-738) (HRP) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593

• Unconjugated
• HRP

• Unconjugated
• HRP

Select

PCSK1 Antibody LS-C681950

Antibody:

PCSK1 Rabbit anti-Rat Polyclonal Antibody

Reactivity:

Rat

Applications:

ELISA

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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