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PCNA

proliferating cell nuclear antigen

Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

Gene Name:	proliferating cell nuclear antigen
Synonyms:	PCNA, Cyclin
Target Sequences:	NM_002592 NP_002583.1 P12004

Publications (11)

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form. Waseem NH, Lane DP. Journal of cell science. 1990 121-9. [PubMed:1695635]

The assessment of proliferating cell nuclear antigen (PCNA)immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S + G2 + M phase fraction (flow cytometric analysis) and prognosis. Woods AL, Hall PA, Shepherd NA, Hanby AM, Waseem NH, Lane DP, Levison DA. Histopathology. 2002 41:165-71. [PubMed:12405950]

Morphogenesis of the medaka cerebellum, with special reference to the mesencephalic sheet, a structure homologous to the rostrolateral part of mammalian anterior medullary velum. Ishikawa Y, Yamamoto N, Yasuda T, Yoshimoto M, Ito H. Brain, behavior and evolution. 2010 75:88-103. [PubMed:20332601]

Molecular mechanism of green microalgae, Dunaliella salina, involved in attenuating balloon injury-induced neointimal formation. Sheu MJ, Cheng HC, Chien YC, Chou PY, Huang GJ, Chen JS, Lin SY, Wu CH. The British journal of nutrition. 2010 104:326-35. (IHC, WB; Human, Rat) [PubMed:20370940]

Functional and physical interaction between the mismatch repair and FA-BRCA pathways. Williams SA, Wilson JB, Clark AP, Mitson-Salazar A, Tomashevski A, Ananth S, Glazer PM, Semmes OJ, Bale AE, Jones NJ, Kupfer GM. Human molecular genetics. 2011 20:4395-410. [PubMed:21865299] [PMC:PMC3196888]

Lentiviral vector-mediated PAX6 overexpression promotes growth and inhibits apoptosis of human retinoblastoma cells. Li L, Li B, Zhang H, Bai S, Wang Y, Zhao B, Jonas JB. Investigative ophthalmology & visual science. 2011 52:8393-400. [PubMed:21948554] Related Antibodies: LS-C97155.

Efficacy of Tie2 receptor antagonism in angiosarcoma. Hasenstein JR, Kasmerchak K, Buehler D, Hafez GR, Cleary K, Moody JS, Kozak KR. Neoplasia (New York, N.Y.). 2012 14:131-40. (IHC; Human) [PubMed:22431921] [PMC:PMC3306258]

Down-regulation of replication factor C-40 (RFC40) causes chromosomal missegregation in neonatal and hypertrophic adult rat cardiac myocytes. Ata H, Shrestha D, Oka M, Ochi R, Jong CJ, Gebb S, Benjamin J, Schaffer S, Hobart HH, Downey J, McMurtry I, Gupte R. PloS one. 2012 7:e39009. [PubMed:22720015] [PMC:PMC3375256] Related Antibodies: LS-C97155.

Hispolon attenuates balloon-injured neointimal formation and modulates vascular smooth muscle cell migration via AKT and ERK phosphorylation. Chien YC, Huang GJ, Cheng HC, Wu CH, Sheu MJ. Journal of natural products. 2012 75:1524-33. (IHC; Mouse) [PubMed:22967007]

Bone mesenchymal stem cell transplantation via four routes for the treatment of acute liver failure in rats. Sun L, Fan X, Zhang L, Shi G, Aili M, Lu X, Jiang T, Zhang Y. International journal of molecular medicine. 2014 34:987-96. (IHC; Human) [Full Text Article] [PubMed:25110277]

Nucleoplasmin is a limiting component in the scaling of nuclear size with cytoplasmic volume. Pan Chen, Miroslav Tomschik, Katherine M Nelson, John Oakey, Jesse C Gatlin, Daniel L Levy. The Journal of cell biology. 2019 December;218:4063-4078. [Full Text Article] [PubMed:31636119] [PMC:PMC6891103]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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