Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Tissue culture supernatant
Specificity and Use
PARP3 antibody was raised against synthetic peptide corresponding to N-terminal aa 8-22 (M8APKPKPWVQTEGPE22) of human PARP-3 (poly(ADP-ribose) polymerase-3) cross-linked to ovalbumin. Percent identity by BLAST analysis: Human (100%); Gorilla (93%); Gibbon, Marmoset (87%); Monkey, Dog (80%).
Recognizes human and mouse PARP-3.
Suitable for use in Immunocytochemistry. Immunocytochemistry: 1:100.
Hybridoma supernatant, 0.1% sodium azide.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint.