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Anti-PARP1 Antibody (phospho-Ser274) LS-C158536

Catalog	Size	Price
LS-C158536-400	400 µl	Unavailable

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Antibody:	Rabbit Polyclonal to Human PARP1
Reactivity:	Human
Application:	Dot Blot
Format:	Unconjugated

Details

Target:	Human PARP1
Host:	Rabbit
Reactivity:	Human (tested or 100% immunogen sequence identity)
Clonality:	Polyclonal
Conjugations:	Unconjugated
Purification:	Protein A purified
Modifications:	Unmodified

Applications

Approved:

Dot Blot (1:500)

Specificity and Use

Blocking Peptide:

LS-E7537 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C158536. Useful for pre-absorption and neutralization of the antibody's antigen binding site.

Epitope:

pSer274

Specificity:

This PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S274 of human PARP1.

Packaging

Presentation:	PBS, 0.09% sodium azide
Storage:	Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Restrictions:	For research use only.

About PARP1

Uniprot: P09874 NCBI: NM_001618 NP_001609.2

Synonyms: PARP1 Antibody, ADPRT Antibody, ADP-ribosyltransferase NAD(+) Antibody, Adp-ribosyltransferase Antibody, ADPRT1 Antibody, ARTD1 Antibody, ADPRT 1 Antibody, Poly(ADP-ribose) synthetase Antibody, Poly(ADP-ribosyl)transferase Antibody, PARP Antibody, Poly [ADP-ribose] polymerase 1 Antibody, PADPRT-1 Antibody, PARP-1 Antibody, Poly (ADP-ribose) polymerase 1 Antibody, Poly(ADP-ribose) polymerase Antibody, Poly[ADP-ribose] synthase 1 Antibody, PPOL Antibody

Description: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR.

(More About PARP1)

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Dot Blot

Dot blot of Phospho-PARP1-S274 Antibody Phospho-specific antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

Requested From:
Date Requested: 8/20/2017

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