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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PARP1 Antibody (N‑Terminus) LS‑C17208
PARP1 antibody LS-C17208 is an unconjugated rabbit polyclonal antibody to PARP1 from human and bovine. Validated for IHC and WB.
Antibody
Catalog
Size
Price
LS-C17208-100
100 µl
$605

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Product Description

PARP1 antibody LS-C17208 is an unconjugated rabbit polyclonal antibody to PARP1 from human and bovine. Validated for IHC and WB.

Specifications

Target
Human PARP1
Synonyms
PARP1, ADPRT, ADP-ribosyltransferase NAD(+), Adp-ribosyltransferase, ADPRT1, ARTD1, ADPRT 1, Poly(ADP-ribose) synthetase, Poly(ADP-ribosyl)transferase, PARP, Poly [ADP-ribose] polymerase 1, PADPRT-1, PARP-1, Poly (ADP-ribose) polymerase 1, Poly(ADP-ribose) polymerase, Poly[ADP-ribose] synthase 1, PPOL
Host
Rabbit
Reactivity
Human, Bovine (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • Western blot (1:1000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
PARP1 antibody was raised against synthetic peptide corresponding to N-terminus of cleavage site (214/215) of human PARP.
Epitope
N-Terminus
Specificity
Specifically recognizes the 85kD fragment of cleaved PARP and can be used as marker for detecting apoptotic cells. Species cross-reactivity: Human and bovine. Mouse and rat demonstrate 86% homology.
Usage
Suitable for use in Western Blot, Immunohistochemistry. Western Blot: 1:1000. Positive control: HeLa and Jurkat cells treated with staurosporine.
Presentation
1 mg/ml BSA (IgG, Protease free), PBS (without Mg2+, Ca2+), pH 7.3, 0.05% Sodium Azide, 50% Glycerol
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About PARP1
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. P09874 NM_001618 NP_001609.2


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Requested From: United States
Date Requested: 10/22/2018

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