PARP1

poly (ADP-ribose) polymerase 1

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

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Antibodies (187)

Proteins (13)

ELISA Kits (12)

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Custom (3)

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PARP1 (212)

Reactivity

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IHC-plus™ PARP1 Antibody (clone A6.4.12) LS-B3432

(4.0) Rating

Antibody:

PARP1 Mouse anti-Human Monoclonal (A6.4.12) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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IHC-plus™ PARP1 Antibody (Gly623, clone 46D11) LS-B5991

(4.0) Rating

Antibody:

PARP1 Rabbit anti-Human Monoclonal (Gly623) (46D11) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$565

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Human PARP1 Protein (Recombinant His-Myc) (Full Length) - LS-G3996

Source:

Sf21 Cells

Tag:

His-Myc

Biological Activity:

Biologically active

Price:

10 µg/$393

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IHC-plus™ PARP1 Antibody (N-Terminus) LS-B3395

(4.0) Rating

Antibody:

PARP1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

250 µl/$485

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IHC-plus™ PARP1 Antibody (aa1-1014) LS-B8446

(4.0) Rating

Antibody:

PARP1 Rabbit anti-Human Polyclonal (aa1-1014) Antibody

Reactivity:

Xenopus, Chicken, Bovine, Mouse, Human

Applications:

ELISA, ICC, IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$485

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Human PARP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78131

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.9 kDa

Price:

20 µg/$150

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Human PARP1 (CLIA) ELISA Kit - LS-F26597

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.27 - 200 ng/ml

Detection:

Chemiluminescent

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$968

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PARP1 Antibody (clone 194C1439) LS-C509

Antibody:

PARP1 Mouse anti-Human Monoclonal (194C1439) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

0.1 mg/$386

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PARP1 Antibody (N-Terminus) LS-C745005

(4.0) Rating

(1) Publication(s)

Antibody:

PARP1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IE, IHC, WB

Format:

Unconjugated

Price:

100 µg/$567

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Human PARP1 (Sandwich ELISA) ELISA Kit - LS-F12266

(4.1) Rating

(2) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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PARP1 Antibody (N-Terminus, clone 5A5) LS-C41045

Antibody:

PARP1 Mouse anti-Mouse Monoclonal (N-Terminus) (5A5) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

25 µg/$276; 100 µg/$354

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PARP1 Antibody (C-Terminus) LS-C17215

Antibody:

PARP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$717

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Human PARP1 (Sandwich ELISA) ELISA Kit - LS-F8694

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$764

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IHC-plus™ PARP1 Antibody (clone 5F1) LS-B12772

(4.0) Rating

Antibody:

PARP1 Mouse anti-Human Monoclonal (5F1) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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PARP1 Antibody LS-C413513

Antibody:

PARP1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$321

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PARP1 Antibody (N-Terminus) LS-C17208

Antibody:

PARP1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Bovine, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$842

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PARP1 Antibody (aa123-151, Biotin) LS-C265573

Antibody:

PARP1 Rabbit anti-Human Polyclonal (aa123-151) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PARP1 Antibody (aa183-214) LS-C99178

Antibody:

PARP1 Rabbit anti-Human Polyclonal (aa183-214) Antibody

Reactivity:

Human

Applications:

Flo, ICC, IF, WB

Format:

Unconjugated

Price:

400 µl/$393

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PARP1 Antibody (aa670-858) LS-C357508

Antibody:

PARP1 Rabbit anti-Human Polyclonal (aa670-858) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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PARP1 Antibody LS-C488647

Antibody:

PARP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

PARP1 Antibody (clone 5F1, Carrier-free) LS-C790462

Antibody:

PARP1 Mouse anti-Human Monoclonal (Carrier-free) (5F1) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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PARP1 Antibody LS-C131308

Antibody:

PARP1 Rabbit anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IP

Format:

Unconjugated

Price:

400 µl/$694

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PARP1 Antibody LS-C408267

Antibody:

PARP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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PARP1 Antibody (aa215-525) LS-C9480

Antibody:

PARP1 Rabbit anti-Human Polyclonal (aa215-525) Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

ICC, IHC, IP, WB

Format:

Unconjugated

Price:

100 µl/$587

Select

PARP1 Antibody LS-C122291

Antibody:

PARP1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Xenopus, Drosophila, Mouse, Rat, Hamster, Human

Applications:

ELISA, IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µg/$686

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