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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PARP1 Antibody (C‑Terminus) LS‑C17217
PARP1 antibody LS-C17217 is an unconjugated rabbit polyclonal antibody to rat PARP1. Validated for ICC and WB.
Antibody
Catalog
Size
Price
LS-C17217-100
100 µl
$575

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Product Description

PARP1 antibody LS-C17217 is an unconjugated rabbit polyclonal antibody to rat PARP1. Validated for ICC and WB.

Specifications

Target
Rat PARP1
Synonyms
PARP1, ADPRT, ADP-ribosyltransferase NAD(+), Adp-ribosyltransferase, ADPRT1, ARTD1, ADPRT 1, Poly(ADP-ribose) synthetase, Poly(ADP-ribosyl)transferase, PARP, Poly [ADP-ribose] polymerase 1, PADPRT-1, PARP-1, Poly (ADP-ribose) polymerase 1, Poly(ADP-ribose) polymerase, Poly[ADP-ribose] synthase 1, PPOL
Host
Rabbit
Reactivity
Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
  • ICC
  • Western blot (1:1000)
Immunogen
PARP1 antibody was raised against synthetic peptide (KLH coupled) corresponding to C-terminal residues adjacent to Asp214 in rat PARP.
Epitope
C-Terminus
Specificity
Detects endogenous levels of the large fragment of rat PARP (89kD) produced by caspase cleavage. Does not react with full length PARP.
Usage
Western Blot: 1:1000. Immunocytochemistry (ABC) 1:100.
Presentation
10 mM HEPES, pH 7.5, 150 mM NaCl, 0.1 mg/ml BSA, 50% Glycerol, No preservatives added
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About PARP1
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. P09874 NM_001618 NP_001609.2


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Requested From: United States
Date Requested: 10/22/2018

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