PARN

poly(A)-specific ribonuclease

3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.

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Products

Antibodies (46)

Proteins (8)

ELISA Kits (2)

Type

Over-Expression Lysate (2)

Primary (46)

Recombinant (6)

Sandwich (2)

Target

PARN (56)

Reactivity

Human (47)

Mouse (8)

Rat (5)

Bat (3)

Bovine (3)

Chicken (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Orangutan (3)

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Application

IHC (19)

IHC-P (4)

WB (46)

ELISA (6)

ICC (1)

IF (3)

IP (2)

Peptide-ELISA (1)

PMA (2)

Host

rabbit (26)

mouse (20)

Product Group

IHCPlus (1)

Isotype

IgG (16)

IgG1 (4)

IgG2a (10)

IgG2b (6)

Clonality

monoclonal mc (20)

polyclonal pc (26)

Clone

OTI1G5 (2)

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OTI4E12 (2)

UMAB143 (2)

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Unconjugated (33)

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Epitope

aa1-266 (20)

aa178-245 (8)

N-Terminus (4)

aa539-589 (1)

aa589-639 (1)

Publications

No (56)

Sample Type

Cell Culture Supernatants (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His-GST-S (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (1)

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PARN Antibody LS-C482729

Antibody:

PARN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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IHC-plus™ PARN Antibody LS-B12265

(4.0) Rating

Antibody:

PARN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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PARN Antibody (HRP) LS-C318436

Antibody:

PARN Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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PARN Antibody (Biotin) LS-C318433

Antibody:

PARN Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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PARN Antibody (FITC) LS-C318432

Antibody:

PARN Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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PARN Antibody LS-C662542

Antibody:

PARN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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PARN Antibody (aa1-266, clone OTI4D12) LS-C336625

Antibody:

PARN Mouse anti-Human Monoclonal (aa1-266) (OTI4D12) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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PARN Antibody (aa1-266, clone OTI4D12, Carrier-free) LS-C789581

Antibody:

PARN Mouse anti-Human Monoclonal (aa1-266) (Carrier-free) (OTI4D12) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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PARN Antibody (aa1-266, clone UMAB143) LS-C796861

Antibody:

PARN Mouse anti-Human Monoclonal (aa1-266) (UMAB143) Antibody

Reactivity:

Human

Applications:

IHC, PMA, WB

Format:

Unconjugated

Price:

100 µl/$493

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PARN Antibody (aa1-266, clone UMAB143, Carrier-free) LS-C799246

Antibody:

PARN Mouse anti-Human Monoclonal (aa1-266) (Carrier-free) (UMAB143) Antibody

Reactivity:

Human

Applications:

IHC, PMA, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$539

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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PARN Antibody LS-C346149

Antibody:

PARN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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Human PARN Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G21036

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

77.5 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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PARN Antibody LS-C768861

Antibody:

PARN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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PARN Antibody LS-C751600

Antibody:

PARN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

PARN Antibody (aa589-639) LS-C290230

Antibody:

PARN Rabbit anti-Human Polyclonal (aa589-639) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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PARN Antibody (aa1-266, clone OTI1G5, Carrier-free) LS-C789571

Antibody:

PARN Mouse anti-Human Monoclonal (aa1-266) (Carrier-free) (OTI1G5) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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PARN Antibody (aa1-266, clone OTI4C9, Carrier-free) LS-C789574

Antibody:

PARN Mouse anti-Human Monoclonal (aa1-266) (Carrier-free) (OTI4C9) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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PARN Antibody (aa1-266, clone OTI2D9, Carrier-free) LS-C789595

Antibody:

PARN Mouse anti-Human Monoclonal (aa1-266) (Carrier-free) (OTI2D9) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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PARN Antibody (aa1-266, clone OTI1G7, Carrier-free) LS-C789597

Antibody:

PARN Mouse anti-Human Monoclonal (aa1-266) (Carrier-free) (OTI1G7) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

Select

PARN Antibody (aa539-589) LS-C290227

Antibody:

PARN Rabbit anti-Human Polyclonal (aa539-589) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

PARN Antibody LS-C803827

Antibody:

PARN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PARN Antibody (N-Terminus) LS-C31344

Antibody:

PARN Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

Select

PARN Antibody (aa1-266, clone OTI4D6) LS-C336601

Antibody:

PARN Mouse anti-Human Monoclonal (aa1-266) (OTI4D6) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

PARN Antibody (aa1-266, clone OTI4E12) LS-C336615

Antibody:

PARN Mouse anti-Human Monoclonal (aa1-266) (OTI4E12) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

PARN Antibody (aa1-266, clone OTI4E12, Carrier-free) LS-C789570

Antibody:

PARN Mouse anti-Human Monoclonal (aa1-266) (Carrier-free) (OTI4E12) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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