Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 5A1] (IgG1) to Human PARK2 / Parkin 2
IHC, Western blot, Immunoprecipitation
Human PARK2 / Parkin 2
Human (tested or 100% immunogen sequence identity)
Monkey, Hamster (at least 90% immunogen sequence identity)
IgG1 Monoclonal [5A1]
IHC (5 µg/ml)
Western blot (5 µg/ml)
Immunoprecipitation (3 µg/ml)
Specificity and Use
A synthetic peptide corresponding to the Cterminal part of human parkin (AYRVDERAAEQARWEAA). Percent identity by BLAST analysis: Human, Chimpanzee (100%); Orangutan, Monkey, Galago, Hamster (94%); Mouse, Rat, Panda (88%); Bovine, Pig (82%).
Human PARK2 / Parkin
Lyophilized from PBS, 1% BSA, 0.05% sodium azide
1 ml Distilled water
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context.