PARK2 / Parkin 2

parkin RBR E3 ubiquitin protein ligase

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30 (PubMed:24896179). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.

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Antibodies (50)

Proteins (11)

ELISA Kits (3)

Type

Cell-Based (1)

Over-Expression Lysate (5)

Primary (50)

Recombinant (6)

Sandwich (2)

Target

PARK2 / Parkin 2 (64)

Reactivity

Human (52)

Mouse (23)

Rat (21)

Bovine (4)

Monkey (3)

Orangutan (3)

Pig (8)

Application

IHC (29)

IHC-P (14)

WB (43)

Flo (2)

ELISA (18)

ICC (3)

IF (12)

IP (2)

Peptide-ELISA (5)

Host

rabbit (46)

mouse (3)

goat (1)

Product Group

IHCPlus (1)

PathPlus Neuro (2)

Isotype

IgG (24)

IgG1,k (1)

IgG2a (1)

IgG3,k (1)

Clonality

monoclonal mc (3)

polyclonal pc (47)

Clone

1H4 (1)

PRK109 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (2)

APC (1)

APC Conjugated (1)

Biotin Conjugated (2)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (38)

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Epitope

aa229-465 (7)

aa1-465 (4)

aa311-360 (4)

70-150 aa (2)

C-Terminus (2)

pSer131 (2)

1-80 aa, N-terminal (1)

Gly12 (1)

Internal (1)

N-Terminus (1)

aa1-437 (1)

aa1-50 (1)

aa101-150 (1)

aa111-140 (1)

aa23-416 (1)

aa300-350 (1)

aa387-417 (1)

aa81-98 (1)

aa83-97 (1)

p131 (1)

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Publications

No (63)

Yes (1)

Sample Type

Adherent Cell Cultures (1)

Cell Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (2)

Tag

10His, N-terminus + Myc, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His-S (1)

His-SUMO (1)

Myc-DDK (Flag) (5)

Species

Human (9)

Source

293T Cells (3)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

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PARK2 / Parkin 2 Antibody (aa111-140) LS-C99184

(4.0) Rating

(1) Publication(s)

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa111-140) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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PARK2 / Parkin 2 Antibody (aa311-360) LS-B5889

Antibody:

PARK2 / Parkin 2 Rabbit anti-Mouse Polyclonal (aa311-360) Antibody

Reactivity:

Mouse

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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PARK2 / Parkin 2 Antibody (aa311-360, FITC) LS-C444561

Antibody:

PARK2 / Parkin 2 Rabbit anti-Mouse Polyclonal (aa311-360) (FITC) Antibody

Reactivity:

Mouse, Rat, Orangutan, Human

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• FITC

• Unconjugated
• FITC

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PARK2 / Parkin 2 Antibody (clone 1H4) LS-C197846

Antibody:

PARK2 / Parkin 2 Mouse anti-Human Monoclonal (1H4) Antibody

Reactivity:

Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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PathPlus™ PARK2 / Parkin 2 Antibody LS-B13850

Neuroscience

(5.0) Rating

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$440

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PARK2 / Parkin 2 Antibody (Internal) LS-C368456

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Bovine, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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PARK2 / Parkin 2 Antibody LS-C336191

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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Human PARK2 / Parkin 2 (Sandwich ELISA) ELISA Kit - LS-F8423

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$902

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PARK2 / Parkin 2 Antibody (aa23-416) LS-C357496

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa23-416) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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PARK2 / Parkin 2 Antibody (aa1-465, HRP) LS-C370102

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa1-465) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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PARK2 / Parkin 2 Antibody (aa1-465, Biotin) LS-C370098

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa1-465) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

• HRP
• Biotin

• HRP
• Biotin

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PARK2 / Parkin 2 Antibody (1-80 aa, N-terminal) LS-C385373

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (1-80 aa, N-terminal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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PathPlus™ PARK2 / Parkin 2 Antibody (aa1-50) LS-B7045

Neuroscience

(5.0) Rating

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$440

Select

PARK2 / Parkin 2 Antibody (N-Terminus) LS-C352631

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Bovine, Rat, Pig, Human, Monkey

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$299

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PARK2 / Parkin 2 Antibody LS-C415931

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

PARK2 / Parkin 2 Antibody (aa387-417) LS-C99185

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa387-417) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

80 µl/$260; 400 µl/$393

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PARK2 / Parkin 2 Antibody (aa229-465, PE) LS-C728458

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa229-465) (PE) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084

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PARK2 / Parkin 2 Antibody (C-Terminus, clone PRK109) LS-C38090

Antibody:

PARK2 / Parkin 2 Mouse anti-Human Monoclonal (C-Terminus) (PRK109) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IP, WB

Format:

Unconjugated

Price:

1 ml/$786

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PARK2 / Parkin 2 Antibody (Gly12) LS-C176171

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (Gly12) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

Human PARK2 / Parkin 2 Protein (Recombinant His) - LS-G2736

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

Select

PARK2 / Parkin 2 Antibody (aa101-150) LS-C117690

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa101-150) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

PARK2 / Parkin 2 Antibody (aa300-350) LS-C93067

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa300-350) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

40 µg/$485

Select

PARK2 / Parkin 2 Antibody (70-150 aa) LS-C385374

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (70-150 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PARK2 / Parkin 2 Antibody (70-150 aa) LS-C381552

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (70-150 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PARK2 / Parkin 2 Antibody (p131) LS-C821901

Antibody:

PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (p131) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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