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| Catalog Number | Size | Price |
|---|---|---|
| LS-C501236-50 | 50 µg | $294 |
| LS-C501236-100 | 100 µg | $360 |
Polyclonal Rabbit anti‑Human PARG Antibody (IF) LS‑C501236
Polyclonal Rabbit anti‑Human PARG Antibody (IF) LS‑C501236
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Specifications
Description
PARG antibody LS-C501236 is an unconjugated rabbit polyclonal antibody to human PARG. Validated for ELISA and IF.
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Recombinant Human Poly(ADP-ribose) glycohydrolase protein (1-348AA)
Specificity
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
Applications
- Immunofluorescence
- ELISA
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About PARG
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Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin, Western blot
Species:
Human, Chimpanzee, Gibbon, Monkey, Guinea pig, Horse
Applications:
Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/18/2024
Date Requested: 4/18/2024
