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Anti-PAPPA / PAPP-A Antibody LS-C9691

Ordering

Wt. Vol. Conc. Price
- 100 µl - $475
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Mouse Monoclonal (IgG2b,k) to Human PAPPA / PAPP-A
Human
IHC, Western blot, ELISA
Unconjugated

Details

Human PAPPA / PAPP-A
Mouse
Human (tested or 100% immunogen sequence identity)
IgG2b,k Monoclonal
Protein A/G purified

Applications

IHC, Western blot, ELISA (1:8000)

Specificity and Use

PAPPA / PAPP-A antibody was raised against purified human PAPP-A.
Recognizes native Pregnancy-associated plasma protein A (human, PAPP-A) Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A. The epitope of this product is different from those of clones 6F172 and 6F173. The epitope is located on the PAPP-A subunit of the heterotetramer. Reactivity: In sandwich ELISA the optimal combination is this product used as coating antibody and biotinylated clone 6F173 used as detection antibody. This product can also be used as detection antibody in sandwich ELISA in combination with a polyclonal antibody towards PAPP-A in coat. This product detects both reduced and unreduced PAPP-A in Western Blot, though reaction to unreduced PAPP-A is less than that of clones 6F172 and 6F173.
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. ELISA: 1:8000. In sandwich ELISA the optimal combination is this product used as coating antibody and biotinylated clone 6F173 used as detection antibody. This product can also be used as detection antibody in sandwich ELISA in combination with a polyclonal antibody towards PAPP-A in coat. Western Blot: Detects both reduced and unreduced PAPP-A in Western Blot, though reaction to unreduced PAPP-A is less than that of clones 6F172 and 6F173.

Packaging

PBS, pH 7.2, 15 mM sodium azide.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
For research use only.

About PAPPA / PAPP-A

Q13219 NM_002581 NP_002572.2

PAPPA Antibody, DIPLA1 Antibody, IGF-dependent IGFBP-4 protease Antibody, PAPPA1 Antibody, PAPA Antibody, PAPP-A Antibody, Pappalysin-1 Antibody, ASBABP2 Antibody, IGFBP-4ase Antibody

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.

Requested From: United States
Date Requested: 9/30/2016

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