PALB2

partner and localizer of BRCA2

Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity.

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Products

Antibodies (21)

Proteins (1)

Type

Primary (21)

Recombinant (1)

Target

PALB2 (22)

Reactivity

Human (21)

Mouse (1)

Rat (1)

Chimpanzee (3)

Application

IHC (2)

IHC-P (1)

WB (20)

Flo (7)

ELISA (8)

IP (2)

Host

rabbit (19)

mouse (2)

Product Group

IHCPlus (1)

Isotype

IgG (13)

IgG1 (2)

Clonality

monoclonal mc (2)

polyclonal pc (19)

Clone

OTI1E7 (2)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

Carrier-free (1)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (13)

Epitope

aa546-574 (7)

aa677-726 (4)

aa1-287 (2)

aa200-250 (2)

aa675-725 (1)

Publications

No (22)

Tag

His, N-Terminal (1)

Species

Human (1)

Source

E. coli (1)

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PALB2 Antibody LS-C108560

Antibody:

PALB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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IHC-plus™ PALB2 Antibody (aa675-725) LS-B11898

(4.0) Rating

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa675-725) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

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PALB2 Antibody LS-C409909

Antibody:

PALB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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PALB2 Antibody (aa546-574) LS-C323766

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa546-574) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

200 µl/$734

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PALB2 Antibody (aa546-574, Biotin) LS-C265523

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa546-574) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PALB2 Antibody (aa546-574, FITC) LS-C265524

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa546-574) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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PALB2 Antibody (aa546-574, PE) LS-C265526

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa546-574) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

PE Conjugated

Price:

200 µl/$952

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PALB2 Antibody (aa546-574, APC) LS-C265522

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa546-574) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

APC Conjugated

Price:

200 µl/$952

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PALB2 Antibody (aa546-574, Azide-free, HRP) LS-C265525

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa546-574) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• APC
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • APC
  • HRP, Azide-free

Select

PALB2 Antibody (aa546-574) LS-C163349

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa546-574) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PALB2 Antibody LS-C667446

Antibody:

PALB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

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PALB2 Antibody (aa200-250) LS-C288057

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa200-250) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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PALB2 Antibody (aa200-250) LS-C286498

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa200-250) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

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PALB2 Antibody (aa1-287, clone OTI1E7) LS-C793954

Antibody:

PALB2 Mouse anti-Human Monoclonal (aa1-287) (OTI1E7) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

PALB2 Antibody (aa1-287, clone OTI1E7, Carrier-free) LS-C790946

Antibody:

PALB2 Mouse anti-Human Monoclonal (aa1-287) (Carrier-free) (OTI1E7) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

PALB2 Antibody (aa677-726) LS-C146550

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa677-726) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

PALB2 Antibody (aa677-726, HRP) LS-C471381

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa677-726) (HRP) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PALB2 Antibody (aa677-726, Biotin) LS-C471379

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa677-726) (Biotin) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PALB2 Antibody (aa677-726, FITC) LS-C471380

Antibody:

PALB2 Rabbit anti-Human Polyclonal (aa677-726) (FITC) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PALB2 Antibody LS-C668391

Antibody:

PALB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

PALB2 Antibody LS-C796567

Antibody:

PALB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$414

Select

Human PALB2 Protein (Recombinant His, N-Terminal) - LS-G145271

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.5 kDa

Price:

50 µg/$419

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