PAK4

p21 protein (Cdc42/Rac)-activated kinase 4

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.

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Products

Antibodies (52)

Proteins (15)

ELISA Kits (2)

Type

Over-Expression Lysate (8)

Primary (52)

Recombinant (7)

Sandwich (1)

Sandwich CLIA (1)

Target

PAK4 (69)

Reactivity

Human (53)

Mouse (27)

Rat (13)

Bat (6)

Bovine (7)

Chimpanzee (3)

Dog (6)

Gibbon (6)

Guinea pig (6)

Hamster (6)

Horse (3)

Monkey (6)

Pig (11)

Rabbit (6)

Xenopus (3)

Zebrafish (3)

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Application

IHC (19)

IHC-P (9)

WB (48)

Flo (8)

ELISA (19)

ICC (2)

IF (3)

IP (3)

Peptide-ELISA (2)

Host

rabbit (45)

mouse (6)

goat (1)

Product Group

IHCPlus (2)

Isotype

IgG (27)

IgG1 (6)

Clonality

monoclonal mc (6)

polyclonal pc (46)

Clone

OTI1C11 (2)

OTI1C7 (2)

OTI3C3 (2)

Format

96-Well Strip Plate (2)

APC (1)

APC Conjugated (3)

Azide-free (2)

Biotin Conjugated (6)

Carrier-free (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (3)

Unconjugated (26)

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Epitope

aa299-542 (8)

aa156-187 (7)

aa187-216 (7)

aa1-308 (6)

aa23-72 (4)

aa268-317 (4)

410-490 aa (1)

aa1-120 (1)

aa25-75 (1)

aa441-490 (1)

pSer474 (1)

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Publications

No (69)

Sample Type

Plasma (2)

Serum (2)

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

His (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (11)

Species

Human (11)

Source

293T Cells (4)

E. coli (3)

HEK 293 Cells (7)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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IHC-plus™ PAK4 Antibody (aa187-216) LS-B10177

(4.0) Rating

Antibody:

PAK4 Rabbit anti-Mouse Polyclonal (aa187-216) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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PAK4 Antibody (phospho-Ser474) LS-C353257

Antibody:

PAK4 Rabbit anti-Human Polyclonal (pSer474) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$315

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PAK4 Antibody (aa25-75) LS-C287254

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa25-75) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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PAK4 Antibody LS-C332245

Antibody:

PAK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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IHC-plus™ PAK4 Antibody LS-B538

(4.0) Rating

Antibody:

PAK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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PAK4 Antibody (aa187-216) LS-C323764

Antibody:

PAK4 Rabbit anti-Mouse Polyclonal (aa187-216) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

200 µl/$734

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PAK4 Antibody (aa187-216, Biotin) LS-C223586

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa187-216) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PAK4 Antibody (aa187-216, FITC) LS-C223587

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa187-216) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

PAK4 Antibody (aa187-216, PE) LS-C223590

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa187-216) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • PE

Select

PAK4 Antibody LS-C667445

Antibody:

PAK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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PAK4 Antibody (aa1-308, clone OTI1C7) LS-C340233

Antibody:

PAK4 Mouse anti-Human Monoclonal (aa1-308) (OTI1C7) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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PAK4 Antibody (aa1-308, clone OTI1C7, Carrier-free) LS-C791178

Antibody:

PAK4 Mouse anti-Human Monoclonal (aa1-308) (Carrier-free) (OTI1C7) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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PAK4 Antibody LS-C370618

Antibody:

PAK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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Human PAK4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70302

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.9 kDa

Price:

20 µg/$1,107

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Human PAK4 Protein (Recombinant His) - LS-G3508

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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PAK4 Antibody (aa156-187) LS-C328138

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa156-187) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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PAK4 Antibody (aa156-187, Biotin) LS-C226091

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa156-187) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

PAK4 Antibody (aa156-187, FITC) LS-C226092

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa156-187) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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PAK4 Antibody (aa156-187, APC) LS-C226090

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa156-187) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

PAK4 Antibody (aa156-187, Azide-free, HRP) LS-C226093

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa156-187) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

PAK4 Antibody (aa156-187, PE) LS-C226097

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa156-187) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

PAK4 Antibody (410-490 aa) LS-C381564

Antibody:

PAK4 Rabbit anti-Human Polyclonal (410-490 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PAK4 Antibody (aa156-187) LS-C99719

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa156-187) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PAK4 Antibody LS-C806479

Antibody:

PAK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PAK4 Antibody (aa299-542) LS-C295748

Antibody:

PAK4 Rabbit anti-Human Polyclonal (aa299-542) Antibody

Reactivity:

Pig, Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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