PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation.

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Products

Antibodies (91)

Proteins (9)

ELISA Kits (7)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (2)

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Primary (91)

Recombinant (5)

Sandwich (2)

Target

PAK1 (107)

Reactivity

Human (91)

Mouse (45)

Rat (52)

Bat (2)

Bovine (6)

Chicken (1)

Dog (4)

Guinea pig (3)

Hamster (1)

Horse (2)

Monkey (4)

Non-Human Primate (1)

Pig (2)

Rabbit (4)

Sheep (2)

Zebra Fish (1)

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Application

IHC (48)

IHC-P (19)

WB (81)

DB (8)

ELISA (41)

ICC (7)

IF (18)

IP (13)

Peptide-ELISA (10)

Host

rabbit (88)

mouse (2)

goat (1)

Product Group

IHCPlus (4)

Isotype

IgG (60)

IgG1,k (2)

Clonality

monoclonal mc (2)

polyclonal pc (89)

Clone

1E11 (1)

4D1 (1)

Format

96-Well Microplate (3)

96-Well Strip Plate (4)

APC (1)

APC Conjugated (5)

Azide-free (3)

Biotin Conjugated (5)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (5)

Preservative Free (1)

Unconjugated (64)

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Epitope

pThr212 (13)

aa252-501 (8)

Thr423 (7)

pThr423 (7)

Internal (3)

pSer204 (3)

140-220 aa (2)

150-230 aa (2)

N-Terminus (2)

pSer199 (2)

pThr84 (2)

Glu195 (1)

Ile206 (1)

Lys198 (1)

aa1-14 (1)

aa1-240 (1)

aa1-50 (1)

aa149-198 (1)

aa165-214 (1)

aa170-219 (1)

aa178-227 (1)

aa238-251 (1)

aa333-545 (1)

aa40-90 (1)

p204 (1)

p212 (1)

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Publications

No (107)

Sample Type

Adherent Cell Cultures (3)

Plasma (2)

Serum (2)

Tag

6His, N-terminus (2)

GST (1)

GST, N-terminus (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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PAK1 Antibody (clone 4D1) LS-C133360

Antibody:

PAK1 Mouse anti-Human Monoclonal (4D1) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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PAK1 Antibody (aa238-251) LS-C55227

Antibody:

PAK1 Goat anti-Human Polyclonal (aa238-251) Antibody

Reactivity:

Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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IHC-plus™ PAK1 Antibody (aa178-227) LS-B7619

(4.0) Rating

Antibody:

PAK1 Rabbit anti-Human Polyclonal (aa178-227) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$440

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IHC-plus™ PAK1 Antibody (clone 1E11) LS-B6113

(4.0) Rating

Antibody:

PAK1 Mouse anti-Human Monoclonal (1E11) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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PAK1 Antibody (Internal) LS-C413063

Antibody:

PAK1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$321

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PAK1 Antibody (Thr423) LS-C99498

Antibody:

PAK1 Rabbit anti-Human Polyclonal (Thr423) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Human PAK1 Protein (Recombinant His-SUMO) (Full Length) - LS-G21650

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

76.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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IHC-plus™ PAK1 Antibody (aa165-214) LS-B7662

(4.0) Rating

Antibody:

PAK1 Rabbit anti-Human Polyclonal (aa165-214) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ PAK1 Antibody LS-B4853

(4.0) Rating

Antibody:

PAK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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PAK1 Antibody (phospho-Ser204) LS-C357282

Antibody:

PAK1 Rabbit anti-Human Polyclonal (pSer204) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$391

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PAK1 Antibody (Internal) LS-C356243

Antibody:

PAK1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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PAK1 Antibody (phospho-Thr212) LS-C356247

Antibody:

PAK1 Rabbit anti-Human Polyclonal (pThr212) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

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PAK1 Antibody LS-C808686

Antibody:

PAK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PAK1 Antibody (phospho-Thr212) LS-C801171

Antibody:

PAK1 Rabbit anti-Human Polyclonal (pThr212) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PAK1 Antibody (p212) LS-C821900

Antibody:

PAK1 Rabbit anti-Human Polyclonal (p212) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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PAK1 Antibody LS-C417622

Antibody:

PAK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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PAK1 Antibody LS-C667440

Antibody:

PAK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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PAK1 Antibody LS-C667442

Antibody:

PAK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

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PAK1 Antibody (150-230 aa) LS-C385351

Antibody:

PAK1 Rabbit anti-Human Polyclonal (150-230 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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PAK1 Antibody (Ile206) LS-C176444

Antibody:

PAK1 Rabbit anti-Human Polyclonal (Ile206) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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PAK1 Antibody (Glu195) LS-C176642

Antibody:

PAK1 Rabbit anti-Human Polyclonal (Glu195) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

PAK1 Antibody LS-C332162

Antibody:

PAK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse

Applications:

ICC, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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PAK1 Antibody (Preservative Free) LS-C815500

Antibody:

PAK1 Rabbit anti-Rat Polyclonal (Preservative Free) Antibody

Reactivity:

Rat

Applications:

ICC, IF, IP, WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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PAK1 Antibody (N-Terminus) LS-C38037

Antibody:

PAK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Guinea pig, Rat, Human, Monkey

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$688

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Mouse/Human/Rat Phospho-PAK1 (Ser204) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1692

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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