Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Locations
Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
PADI4 / PAD4
peptidyl arginine deiminase, type IV
Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
| Gene Name: | peptidyl arginine deiminase, type IV |
| Synonyms: | PADI4, HL-60 PAD, PAD4, PAD, PDI5, PDI4, PADI-H protein, PADI5, Peptidylarginine deiminase IV |
| Target Sequences: | NM_012387 NP_036519.2 Q9UM07 |
Publications (3)
1
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix. Yuzhalin AE, Gordon-Weeks AN, Tognoli ML, Jones K, Markelc B, Konietzny R, Fischer R, Muth A, O'Neill E, Thompson PR, Venables PJ, Kessler BM, Lim SY, Muschel RJ. Nature communications. 2018 November;9:4783. [Full Text Article]
[PubMed:30429478]
[PMC:PMC6235861]
2
Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis. Carmelo Carmona-Rivera, Philip M Carlucci, Rishi R Goel, Eddie James, Stephen R Brooks, Cliff Rims, Victoria Hoffmann, David A Fox, Jane H Buckner, Mariana J Kaplan. JCI insight. 2020 July;5: [Full Text Article]
[PubMed:32484790]
[PMC:PMC7406272]
3
Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa. Angel S Byrd, Carmelo Carmona-Rivera, Liam J O'Neil, Philip M Carlucci, Cecilia Cisar , Avi Z Rosenberg, Michelle L Kerns, Julie A Caffrey, Stephen M Milner, Justin M Sacks, Oluseyi Aliu, Kristen P Broderick, Jonathan S Reichner, Lloyd S Miller, Sewon Kang, William H Robinson , Ginette A Okoye, Mariana J Kaplan. Science translational medicine. 2019 Sep;11:eaav5908. [Full Text Article]
[PubMed:31484788]
☰ Filters
Products
Antibodies
(40)
ELISA Kits
(8)
Proteins
(8)
Type
Over-Expression Lysate
(2)
Primary
(40)
Recombinant
(6)
Sandwich
(7)
Sandwich CLIA
(1)
Target
PADI4 / PAD4
(56)
Reactivity
Human
(43)
Mouse
(7)
Rat
(8)
Bat
(3)
Chicken
(4)
Chimpanzee
(3)
Gibbon
(3)
Monkey
(4)
Porcine
(1)
Rabbit
(4)
Application
IHC
(19)
IHC-P
(10)
WB
(37)
Flo
(5)
ChrIP
(1)
ELISA
(7)
ICC
(2)
IF
(8)
IP
(1)
Peptide-ELISA
(2)
Host
rabbit
(28)
mouse
(11)
goat
(1)
Product Group
IHCPlus
(2)
Isotype
IgG
(10)
IgG1
(7)
IgG2a
(4)
Clonality
monoclonal mc
(11)
polyclonal pc
(29)
Clone
OTI3E1
(2)
OTI4H5
(2)
OTI5B7
(2)
OTI5C10
(2)
OTI5E7
(2)
OTI6A2
(1)
Format
12 x 8-Well Microstrips
(1)
96-Well Microplate
(1)
96-Well Strip Plate
(6)
APC
(1)
APC Conjugated
(1)
Biotin Conjugated
(2)
Carrier-free
(6)
Cy3 Conjugated
(1)
Cy7 Conjugated
(1)
FITC Conjugated
(2)
HRP Conjugated
(2)
PE Conjugated
(1)
Unconjugated
(30)
Epitope
aa1-300
(8)
aa299-588
(4)
aa398-447
(4)
N-Terminus
(2)
aa1-250
(1)
aa2-14
(1)
aa326-611
(1)
aa492-512
(1)
aa512-544
(1)
Publications
No
(55)
Yes
(1)
Sample Type
Cell Culture Supernatants
(1)
Cell Lysates
(1)
Plasma
(5)
Serum
(5)
Tissue Homogenates
(2)
Tag
6His, N-terminus
(2)
GST, N-terminus
(2)
His-T7
(1)
Myc-DDK (Flag)
(3)
Species
Human
(7)
Source
293T Cells
(1)
E. coli
(3)
HEK 293 Cells
(2)
Wheat Germ Extract
(2)
Purification
Purified
(1)
Low Endotoxin Level
Low endotoxin level
(2)
PADI4 / PAD4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
50 µg/$440; 100 µg/$480
PADI4 / PAD4 Mouse anti-Human Monoclonal (OTI5B7) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
PADI4 / PAD4 Rabbit anti-Human Polyclonal (aa398-447) Antibody
Human
WB
Unconjugated
100 µl/$424
PADI4 / PAD4 Rabbit anti-Human Polyclonal (aa398-447) (FITC) Antibody
Chicken, Rabbit, Mouse, Rat, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
Sandwich
96-Well Microplate
Human
0.19 - 12 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
Sandwich
96-Well Strip Plate
Human
0.188 - 12 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$863
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$834
PADI4 / PAD4 Goat anti-Human Polyclonal (aa2-14) Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
PADI4 / PAD4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PADI4 / PAD4 Rabbit anti-Human Polyclonal (aa1-300) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PADI4 / PAD4 Mouse anti-Human Monoclonal (OTI5E7) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
PADI4 / PAD4 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
PADI4 / PAD4 Mouse anti-Human Monoclonal (OTI3E1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PADI4 / PAD4 Mouse anti-Human Monoclonal (aa299-588) (Carrier-free) (OTI3E1) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PADI4 / PAD4 Rabbit anti-Human Polyclonal (aa1-250) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
PADI4 / PAD4 Rabbit anti-Mouse Polyclonal Antibody
Mouse
IHC, IHC-P
Unconjugated
0.1 ml/$386
PADI4 / PAD4 Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
PADI4 / PAD4 Mouse anti-Human Monoclonal (OTI4H5) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$469
PADI4 / PAD4 Mouse anti-Human Monoclonal (Carrier-free) (OTI4H5) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$512
PADI4 / PAD4 Mouse anti-Human Monoclonal (Carrier-free) (OTI6A2) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PADI4 / PAD4 Rabbit anti-Human Polyclonal Antibody
Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PADI4 / PAD4 Rabbit anti-Human Polyclonal (aa326-611) Antibody
Human
ChrIP, ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
PADI4 / PAD4 Mouse anti-Human Monoclonal (OTI5C10) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
Sandwich
96-Well Strip Plate
Monkey
0.19 - 12 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Viewing 1-25
of 56
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
