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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PACE4 / PCSK6 Antibody (Internal) IHC‑plus™ LS‑A8407
PCSK6 antibody LS-A8407 is an unconjugated rabbit polyclonal antibody to PCSK6 (PACE4) from human and rabbit. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-A8407-50
50 µg (1 mg/ml)
Unavailable
In Stock for Immediate Shipment

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Product Description

PCSK6 antibody LS-A8407 is an unconjugated rabbit polyclonal antibody to PCSK6 (PACE4) from human and rabbit. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
About PACE4 / PCSK6
PACE4 / PCSK6 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. P29122 NM_002570 NP_002561.1

PCSK6 Antibody, PACE4 Antibody, SPC4 Antibody


Specifications

Target
Human PACE4 / PCSK6
Host
Rabbit
Reactivity
Human, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 - 15 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
PACE4 / PCSK6 antibody was raised against synthetic 16 amino acid peptide from internal region of human PACE4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rabbit (100%); Marmoset (94%); Mouse, Rat, Elephant, Panda, Bovine, Dog, Horse, Pig, Opossum (88%); Bat (81%).
Blocking Peptide
LS-E29407 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A8407. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Internal
Specificity
Human PACE4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, less than 0.1% sodium azide.
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Immunohistochemistry

Anti-PACE4 antibody LS-A8407 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PACE4 antibody LS-A8407 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-PACE4 antibody LS-A8407 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PACE4 antibody LS-A8407 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-PACE4 antibody LS-A8407 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PACE4 antibody LS-A8407 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-PACE4 antibody LS-A8407 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PACE4 antibody LS-A8407 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Requested From: 
Date Requested: 7/15/2018

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