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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PABPN1 / PABP2 Antibody (N‑Terminus) IHC‑plus™ LS‑B5706 Best Seller
Note: This antibody replaces LS-C110533
PABP2 antibody LS-B5706 is an unconjugated rabbit polyclonal antibody to PABP2 (PABPN1) from human, rat, bovine and other species. Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-B5706-50
50 µg (1 mg/ml)
Unavailable

Popular PABPN1 / PABP2 Products

Anti-PABPN1 / PABP2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8482 dilution 1:50-1:100.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, ICC, Western blot, Flow Cytometry
Antibody
Species: Human
Applications: Western blot, ELISA
Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5706 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Chimpanzee, Monkey, Rat, Bovine, Dog, Guinea pig, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Western blot
Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5706 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Chimpanzee, Monkey, Rat, Bovine, Dog, Guinea pig, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Western blot

Product Description

PABP2 antibody LS-B5706 is an unconjugated rabbit polyclonal antibody to PABP2 (PABPN1) from human, rat, bovine and other species. Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues.
About PABPN1 / PABP2
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Q86U42 NM_004643 NP_004634.1

PABPN1 Antibody, PABP2 Antibody, Poly(A)-binding protein 2 Antibody, OPMD Antibody, PABII Antibody, PABP-2 Antibody, Poly(A) binding protein 2 Antibody, Poly(A) binding protein II Antibody, Poly(A)-binding protein II Antibody, PAB2 Antibody


Specifications

Target
Human PABPN1 / PABP2
Host
Rabbit
Reactivity
Human, Monkey, Rat, Bovine, Dog, Guinea pig, Pig, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Mouse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with Biotin, HRP, FITC.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • Western blot (0.2 - 1 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
PABPN1 / PABP2 antibody was raised against synthetic peptide from N-Terminus of human PABPN1 (Q86U42, NP_004634). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Galago, Marmoset, Rat, Dog, Bovine, Rabbit, Pig, Guinea pig (100%); Mouse, Opossum (92%).
Blocking Peptide
LS-E14814 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-B5706. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
N-Terminus
Specificity
Human PABPN1
Usage
Western Blot: Suggested dilution at 1 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.
Presentation
Lyophilized from PBS with 2% sucrose
Reconstitution
50 µl Distilled water
Storage
Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5706 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5706 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

PABPN1 antibody LS-B5706 Western blot of NCI-H226 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PABPN1 antibody LS-B5706 Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5706 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5706 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

PABPN1 antibody LS-B5706 Western blot of NCI-H226 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PABPN1 antibody LS-B5706 Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5706 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5706 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

PABPN1 antibody LS-B5706 Western blot of NCI-H226 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PABPN1 antibody LS-B5706 Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5706 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5706 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

PABPN1 antibody LS-B5706 Western blot of NCI-H226 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PABPN1 antibody LS-B5706 Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/25/2018

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