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PA26 / SESN1

sestrin 1

PA26 / SESN1 is a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene Name: sestrin 1
Synonyms: SESN1, PA26, p53-regulated protein PA26, p53 activated gene 26, SEST1, Sestrin 1, Sestrin-1
Target Sequences: NM_014454 NP_055269.1 Q9Y6P5

Publications (1)

1
MiR-16-5p targets SESN1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation. Cai B, Ma M, Chen B, Li Z, Abdalla BA, Nie Q, Zhang X. Cell death & disease. 2018 March;9:367. (Rat) [Full Text Article] [PubMed:29511169] [PMC:PMC5840423] Related Antibodies: LS-C145280.

☰ Filters
Antibodies (30)
ELISA Kits (9)
Proteins (2)
Custom (2)
Primary (30)
Recombinant (2)
Sandwich (6)
Sandwich CLIA (1)
PA26 / SESN1 (41)
Human (25)
Mouse (28)
Rat (10)
Bat (6)
Bovine (6)
Chicken (6)
Chimpanzee (6)
Dog (6)
Gibbon (6)
Guinea pig (6)
Horse (6)
Monkey (6)
Orangutan (6)
Pig (6)
Rabbit (3)
Xenopus (3)
Zebrafish (3)
IHC (6)
IHC-P (2)
WB (27)
Flo (2)
ELISA (8)
Peptide-ELISA (2)
rabbit (30)
IgG (11)
polyclonal pc (30)
12 x 8-Well Microstrips (1)
96-Well Microplate (1)
96-Well Strip Plate (7)
APC (1)
APC Conjugated (1)
Biotin Conjugated (4)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (1)
Unconjugated (14)
aa45-492 (8)
aa208-257 (4)
aa375-424 (4)
240-320 aa, Internal (1)
Internal (1)
aa138-163 (1)
aa14-43 (1)
aa224-337 (1)
aa271-320 (1)
aa312-341 (1)
No (40)
Yes (1)
Cell Lysates (2)
Plasma (5)
Serum (5)
Tissue Homogenates (4)
GST, N-terminus (1)
His-T7 (1)
Human (1)
Mouse (1)
E. coli (1)
Wheat Germ Extract (1)
PA26 / SESN1 Antibody - SESN1 antibody Western blot of Rat Brain lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PA26 / SESN1 Rabbit anti-Rat Polyclonal (aa375-424) Antibody
Rat
WB
Unconjugated
100 µl/$424
PA26 / SESN1 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SESN1 Antibody. The picture on the right is blocked with the synthesized peptide.
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PA26 / SESN1 Rabbit anti-Human Polyclonal (aa271-320) Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PA26 / SESN1 Antibody - Western blot analysis of extracts of various cell lines.
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PA26 / SESN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Flo, WB
Unconjugated
100 µl/$389; 200 µl/$503
PA26 / SESN1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$854
PA26 / SESN1 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer at dilution of 1:100
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PA26 / SESN1 Rabbit anti-Human Polyclonal (aa224-337) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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PA26 / SESN1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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PA26 / SESN1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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PA26 / SESN1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
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PA26 / SESN1 Rabbit anti-Human Polyclonal (240-320 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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PA26 / SESN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
PA26 / SESN1 Antibody - Western blot of Sestrin-1 antibody in mouse heart tissue lysates (35 ug/lane). Sestrin-1 (arrow) was detected using the purified antibody.
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PA26 / SESN1 Rabbit anti-Human Polyclonal (aa312-341) Antibody
Mouse, Human
Flo, WB
Unconjugated
400 µl/$393
PA26 / SESN1 Antibody - Immunohistochemical analysis of SESN1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PA26 / SESN1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
PA26 / SESN1 Antibody - 1:100 staining human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PA26 / SESN1 Rabbit anti-Human Polyclonal (aa138-163) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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PA26 / SESN1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
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PA26 / SESN1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
PA26 / SESN1 Antibody - Western Blot; Sample: Recombinant SESN1, Mouse.
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PA26 / SESN1 Rabbit anti-Mouse Polyclonal (aa45-492) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
PA26 / SESN1 Antibody - Western Blot; Sample: Recombinant SESN1, Mouse.
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PA26 / SESN1 Rabbit anti-Mouse Polyclonal (aa45-492) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
PA26 / SESN1 Antibody - Western Blot; Sample: Recombinant SESN1, Mouse.
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PA26 / SESN1 Rabbit anti-Mouse Polyclonal (aa45-492) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
PA26 / SESN1 Antibody - Western Blot; Sample: Recombinant SESN1, Mouse.
Select
PA26 / SESN1 Rabbit anti-Mouse Polyclonal (aa45-492) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
PA26 / SESN1 Antibody - Western Blot; Sample: Recombinant SESN1, Mouse.
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PA26 / SESN1 Rabbit anti-Mouse Polyclonal (aa45-492) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
PA26 / SESN1 Antibody - Western Blot; Sample: Recombinant SESN1, Mouse.
Select
PA26 / SESN1 Rabbit anti-Mouse Polyclonal (aa45-492) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
PA26 / SESN1 Antibody - Western Blot; Sample: Recombinant SESN1, Mouse.
Select
PA26 / SESN1 Rabbit anti-Mouse Polyclonal (aa45-492) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
PA26 / SESN1 Antibody - Western Blot; Sample: Recombinant SESN1, Mouse.
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PA26 / SESN1 Rabbit anti-Mouse Polyclonal (aa45-492) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
PA26 / SESN1 Antibody - Western blot of Human THP-1. SESN1 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PA26 / SESN1 Rabbit anti-Human Polyclonal (aa208-257) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
PA26 / SESN1 Antibody - Western blot of Sestrin-1 Antibody in mouse heart tissue lysates (35 ug/lane). Sestrin-1 (arrow) was detected using the purified antibody.
Select
PA26 / SESN1 Rabbit anti-Human Polyclonal (aa14-43) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
Viewing 1-25 of 41 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).