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Anti-p66 / SHC Antibody (phospho-Tyr317) LS-C10124

Ordering

Wt. Vol. Conc. Price
- 200 µl - $575
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular p66 / SHC Antibodies

Anti-p66 / SHC Antibody (phospho-Ser36, clone 6E10) LS-C10125
Mouse Monoclonal [clone 6E10] (IgG1) to Human p66 / SHC
Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Pig
Western blot, ELISA
Unconjugated
Anti-p66 / SHC Antibody (phospho-Tyr427) LS-C34237
Rabbit Polyclonal (IgG) to Human p66 / SHC
Human, Mouse, Rat
IHC - Paraffin, Immunofluorescence, Western blot
Unconjugated
Immunohistochemistry Image
Anti-p66 / SHC Antibody (clone 3F4) IHC-plus™ LS-B4416
Mouse Monoclonal [clone 3F4] (IgG,k) to Human p66 / SHC
Human
IHC - Paraffin, Immunofluorescence, Western blot, ELISA, Proximity Ligation Assay
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human p66 / SHC
Human, Mouse
Western blot
Unconjugated

Details

Human p66 / SHC
Rabbit
Human, Mouse (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

Western blot

Specificity and Use

p66 / SHC antibody was raised against synthetic peptide (FDDPS[pY]VN-C) corresponding to aa312-319 of human p52 SHC, containing a C-terminal cysteine (KLH). This motif is the Grb2 binding site.
pTyr317
Recognizes phosphorylated human SHC protein isoforms, Mr 46kD, 52kD and 67kD. In long exposures, additional proteins of Mr 110 and 180 are detected in EGF-treated lysates. Species cross-reactivity: mouse.
Suitable for use in Western Blot. Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.

Packaging

0.2 M Tris-HCl, pH 7.4, 100 mM glycine, 150 mM sodium chloride, 0.1 mM EDTA, 5 mg/ml BSA, 0.05% sodium azide, 30% glycerol.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About p66 / SHC

P29353 NM_003029 NP_003020.2

SHC1 Antibody, p46 shc Antibody, p52 shc Antibody, SH2 domain protein C1 Antibody, p66 Antibody, SHCA Antibody, SHC Antibody, SHC-transforming protein 1 Antibody, SHC-transforming protein 3 Antibody, SHC-transforming protein A Antibody

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.

Requested From: United States
Date Requested: 12/2/2016

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