Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
SHC1 Antibody, p46 shc Antibody, p52 shc Antibody, SH2 domain protein C1 Antibody, p66 Antibody, SHCA Antibody, SHC Antibody, SHC-transforming protein 1 Antibody, SHC-transforming protein 3 Antibody, SHC-transforming protein A Antibody
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.
Anti-SHC1 antibody IHC of human colon, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4416 concentration 1 ug/ml.
Anti-SHC1 antibody IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4416 concentration 1 ug/ml.
Anti-SHC1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4416 concentration 1 ug/ml.
Immunofluorescence of monoclonal antibody to SHC1 on A-431 cells (antibody concentration 10 ug/ml).
SHC1 monoclonal antibody clone 3F4 Western blot of SHC1 expression in A-431.
Enzyme-Linked Immunosorbent Assay
Detection limit for recombinant GST tagged SHC1 is approximately 0.03 ng/ml as a capture antibody.
Proximity Ligation Assay
Proximity Ligation Analysis (PLA) of protein-protein interactions between PIK3R1 and SHC1 HeLa cells were stained with anti-PIK3R1 rabbit purified polyclonal 1:1200 and anti-SHC1 mouse monoclonal antibody 1:50. Signals were detected by Duolink 30 Detection.