p66 / SHC

SHC (Src homology 2 domain containing) transforming protein 1

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

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Antibodies (80)

Proteins (11)

ELISA Kits (4)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Over-Expression Lysate (7)

Primary (80)

Recombinant (4)

Sandwich (1)

Target

p66 / SHC (95)

Reactivity

Human (75)

Mouse (52)

Rat (42)

Bat (4)

Bovine (10)

Chimpanzee (4)

Dog (8)

Gibbon (3)

Guinea pig (3)

Hamster (3)

Horse (9)

Monkey (9)

Orangutan (3)

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Rabbit (3)

Sheep (1)

Xenopus (5)

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IHC (46)

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WB (73)

Flo (6)

ELISA (25)

ICC (1)

IF (17)

IP (5)

Peptide-ELISA (7)

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rabbit (67)

mouse (13)

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IHCPlus (2)

Isotype

IgG (43)

IgG,k (1)

IgG1 (12)

Clonality

monoclonal mc (14)

polyclonal pc (66)

Clone

2F7C7 (1)

3F4 (1)

6E10 (1)

EP332Y (1)

OTI1D3 (2)

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Epitope

pTyr427 (10)

aa272-559 (8)

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aa378-405 (7)

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370-450 aa (2)

pTyr317 (2)

10-90 aa (1)

290-370 aa (1)

Glu343 (1)

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N-Terminus (1)

SH2 Domain (1)

aa300-350 (1)

aa315-364 (1)

aa393-442 (1)

aa424-440 (1)

aa536-564 (1)

p349 (1)

p427 (1)

pSer36 (1)

pTyr239/Tyr240 (1)

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Publications

No (94)

Yes (1)

Sample Type

Adherent Cell Cultures (3)

Cell Lysates (1)

Tissue Homogenates (1)

Tag

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GST, N-terminus (1)

His (1)

His-T7 (1)

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Species

Human (8)

Source

293T Cells (3)

E. coli (2)

HEK 293 Cells (5)

Wheat Germ Extract (1)

Purification

Purified (1)

Select

IHC-plus™ p66 / SHC Antibody (clone 3F4) LS-B4416

(4.0) Rating

Antibody:

p66 / SHC Mouse anti-Human Monoclonal (3F4) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, PLA, WB

Format:

Unconjugated

Price:

50 µg/$460

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p66 / SHC Antibody (N-Terminus) LS-C10119

(4.1) Rating

(2) Publication(s)

Antibody:

p66 / SHC Mouse anti-Human Monoclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$578; 100 µg/$925

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IHC-plus™ p66 / SHC Antibody (SH2 Domain, clone EP332Y) LS-B7922

(4.0) Rating

Antibody:

p66 / SHC Rabbit anti-Human Monoclonal (SH2 Domain) (EP332Y) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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p66 / SHC Antibody (phospho-Ser36, clone 6E10) LS-C10125

Antibody:

p66 / SHC Mouse anti-Human Monoclonal (pSer36) (6E10) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Pig, Horse, Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$578; 100 µg/$919

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p66 / SHC Antibody (clone OTI3A1) LS-C115098

Antibody:

p66 / SHC Mouse anti-Human Monoclonal (OTI3A1) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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p66 / SHC Antibody (clone OTI3A1, Carrier-free) LS-C797234

Antibody:

p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI3A1) Antibody

Reactivity:

Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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p66 / SHC Antibody (aa371-420) LS-C81553

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal (aa371-420) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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p66 / SHC Antibody (aa424-440) LS-C313035

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal (aa424-440) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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Human p66 / SHC (Sandwich ELISA) ELISA Kit - LS-F8286

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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p66 / SHC Antibody (aa536-564) LS-C357582

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal (aa536-564) Antibody

Reactivity:

Mouse, Sheep, Rat, Pig, Horse, Bat, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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p66 / SHC Antibody (phospho-Tyr427) LS-C91357

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal (pTyr427) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µg/$570

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p66 / SHC Antibody (clone OTI1H8) LS-C115116

Antibody:

p66 / SHC Mouse anti-Human Monoclonal (OTI1H8) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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p66 / SHC Antibody (clone OTI1H8, Carrier-free) LS-C797239

Antibody:

p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI1H8) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

p66 / SHC Antibody LS-C801581

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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p66 / SHC Antibody (phospho-Tyr349) LS-C801064

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal (pTyr349) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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p66 / SHC Antibody (phospho-Tyr427) LS-C801065

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal (pTyr427) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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p66 / SHC Antibody LS-C752848

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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p66 / SHC Antibody LS-C752850

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

p66 / SHC Antibody LS-C490069

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

Select

p66 / SHC Antibody (p349) LS-C825784

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal (p349) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

p66 / SHC Antibody (clone OTI1D3) LS-C115115

Antibody:

p66 / SHC Mouse anti-Human Monoclonal (OTI1D3) Antibody

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

p66 / SHC Antibody (clone OTI1D3, Carrier-free) LS-C784608

Antibody:

p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI1D3) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

p66 / SHC Antibody (clone OTI3H1) LS-C115143

Antibody:

p66 / SHC Mouse anti-Human Monoclonal (OTI3H1) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

p66 / SHC Antibody (clone OTI3H1, Carrier-free) LS-C797252

Antibody:

p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI3H1) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

p66 / SHC Antibody LS-C499763

Antibody:

p66 / SHC Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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