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P450SCC / CYP11A1

cytochrome P450, family 11, subfamily A, polypeptide 1

P450SCC / CYP11A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide.

Gene Name: cytochrome P450, family 11, subfamily A, polypeptide 1
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP11A1, Cholesterol 20-22 desmolase, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450C11A1, CYP11A, Cytochrome P450(scc), p450SCC, Steroid 20-22-lyase, CYPXIA1
Target Sequences: NM_000781 NP_000772.2 P05108

Publications (1)

1
Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. O'Shaughnessy PJ, Monteiro A, Bhattacharya S, Fraser MJ, Fowler PA. Molecular human reproduction. 2013 19:177-87. (WB; Human) [PubMed:23197595] Related Antibodies: LS-B3997.

☰ Filters
Antibodies (64)
Proteins (10)
ELISA Kits (8)
Custom (4)
Over-Expression Lysate (2)
Primary (64)
Recombinant (8)
Sandwich (4)
P450SCC / CYP11A1 (82)
Human (41)
Mouse (23)
Rat (18)
Bovine (8)
Chimpanzee (3)
Cow (8)
Monkey (1)
Pig (17)
IHC (10)
IHC-Fr (1)
IHC-P (6)
WB (62)
ELISA (10)
ICC (2)
IF (5)
Peptide-ELISA (2)
rabbit (63)
mouse (1)
Product Group
IHCPlus (2)
IgG (26)
polyclonal pc (64)
96-Well Strip Plate (8)
APC (4)
APC Conjugated (5)
Biotin Conjugated (7)
Cy3 Conjugated (4)
Cy7 Conjugated (4)
FITC Conjugated (7)
HRP Conjugated (7)
PE Conjugated (5)
Unconjugated (25)
aa329-526 (8)
aa391-515 (8)
aa392-521 (8)
aa44-287 (8)
aa288-337 (4)
390-470 aa, C-terminal (1)
C-Terminus (1)
aa398-447 (1)
aa40-521 (1)
aa457-502 (1)
aa507-521 (1)
aa53-66 (1)
aa88-120 (1)
No (81)
Yes (1)
Plasma (3)
Serum (3)
Tissue Homogenates (3)
GST (1)
GST, N-terminus (1)
His (1)
His-SUMO (1)
His-T7 (3)
Myc-DDK (Flag) (3)
Bovine (1)
Human (6)
Mouse (1)
Pig (1)
293T Cells (1)
E. coli (5)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
P450SCC / CYP11A1 Antibody - Anti-CYP11A1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal (aa288-337) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
P450SCC / CYP11A1 Antibody - Anti-CYP11A1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal (aa288-337) (HRP) Antibody
Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
P450SCC / CYP11A1 Antibody - Anti-CYP11A1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal (aa288-337) (Biotin) Antibody
Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
P450SCC / CYP11A1 Antibody - Anti-CYP11A1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal (aa288-337) (FITC) Antibody
Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
P450SCC / CYP11A1 Antibody - Western blot of anti-CYP11A1 Antibody in HepG2 cell line lysates (35 ug/lane). CYP11A1(arrow) was detected using the purified antibody.
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal (aa88-120) Antibody
Human
WB
Unconjugated
400 µl/$393
P450SCC / CYP11A1 Antibody - Western blot of P450SCC / CYP11A1 antibody.
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P450SCC / CYP11A1 Rabbit anti-Cow Polyclonal (aa391-515) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$328; 200 µl/$379; 500 µl/$547; 1 ml/$648; 2 ml/$883; 5 ml/$1,471
P450SCC / CYP11A1 Protein - Recombinant Cytochrome P450 11A1 By SDS-PAGE
Select
E. coli
His
26.6 kDa
10 µg/$282; 50 µg/$447; 1 mg/$2,005; 200 µg/$892; 100 µg/$715; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
P450SCC / CYP11A1 Antibody - Immunofluorescent analysis of Cytochrome P450 11A1 staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, WB
Unconjugated
100 µl/$299
P450SCC / CYP11A1 Antibody - P450SCC / CYP11A1 antibody. IHC(P): Human Placenta Tissue.
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal (aa507-521) Antibody
Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
P450SCC / CYP11A1 Antibody - CYP11A1 antibody Western blot. All lanes: Anti CYP11A1 at 0.5 ug/ml. Lane 1: Rat Testis Tissue Lysate at 50 ug. Lane 2: Mouse Testis Tissue Lysate at 50 ug. Lane 3: Mouse Brain Tissue Lysate at 50 ug. Predicted band size: 60 kD. Observed band size: 60 kD.
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P450SCC / CYP11A1 Rabbit anti-Mouse Polyclonal (aa53-66) Antibody
Mouse, Rat
WB
Unconjugated
10 µg/$318; 100 µg/$470
P450SCC / CYP11A1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
P450SCC / CYP11A1 Protein
Select
E. coli
His-SUMO
72.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
P450SCC / CYP11A1 Antibody - Immunohistochemistry of paraffin-embedded Human placenta using CYP11A1 Polyclonal Antibody at dilution of 1:150 (40x lens).
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
P450SCC / CYP11A1 Antibody - Immunohistochemistry of paraffin-embedded Rat lung using CYP11A1 Polyclonal Antibody at dilution of 1:100 (40x lens).
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
P450SCC / CYP11A1 Antibody - Immunofluorescence analysis of HeLa cells using CYP11A1 antibodyat dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
P450SCC / CYP11A1 Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal (aa40-521) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
P450SCC / CYP11A1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
P450SCC / CYP11A1 Protein - 12.5% SDS-PAGE of human CYP11A1 stained with Coomassie Blue
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Wheat Germ Extract
GST
86.5 kDa
2 µg/$439
P450SCC / CYP11A1 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
P450SCC / CYP11A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
Select
P450SCC / CYP11A1 Rabbit anti-Human Polyclonal (aa457-502) Antibody
Mouse, Rat, Human
ICC, WB
Unconjugated
50 µl/$321; 100 µl/$403
P450SCC / CYP11A1 Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using CYP11A1 Polyclonal Antibody at dilution of 1:50.
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P450SCC / CYP11A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
P450SCC / CYP11A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
P450SCC / CYP11A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
P450SCC / CYP11A1 Antibody - Western blot of CYP11A1 antibody
Select
P450SCC / CYP11A1 Rabbit anti-Human Polyclonal (390-470 aa, C-terminal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Viewing 1-25 of 82 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).