OTULIN / FAM105B

family with sequence similarity 105, member B

Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.

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Products

Antibodies (13)

Proteins (3)

ELISA Kits (2)

Type

Custom (1)

Over-Expression Lysate (2)

Primary (13)

Recombinant (1)

Sandwich (1)

Target

OTULIN / FAM105B (18)

Reactivity

Human (14)

Mouse (9)

Chimpanzee (3)

Application

IHC (7)

IHC-P (1)

WB (12)

Flo (7)

ELISA (6)

IP (2)

Host

rabbit (13)

Isotype

IgG (8)

Clonality

polyclonal pc (13)

Format

96-Well Strip Plate (2)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (5)

Epitope

aa99-128 (7)

aa238-287 (4)

aa302-352 (1)

aa75-125 (1)

Publications

No (18)

Tag

His (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Low Endotoxin Level

Low endotoxin level (1)

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OTULIN / FAM105B Antibody (aa99-128) LS-C165928

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa99-128) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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OTULIN / FAM105B Antibody (aa99-128) LS-C321265

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa99-128) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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OTULIN / FAM105B Antibody (aa99-128, Biotin) LS-C256977

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa99-128) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

OTULIN / FAM105B Antibody (aa99-128, FITC) LS-C256976

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa99-128) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

OTULIN / FAM105B Antibody (aa99-128, APC) LS-C256974

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa99-128) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

OTULIN / FAM105B Antibody (aa99-128, Azide-free, HRP) LS-C256978

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa99-128) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

OTULIN / FAM105B Antibody (aa99-128, PE) LS-C256981

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa99-128) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

OTULIN / FAM105B Antibody (aa75-125) LS-C763331

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa75-125) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295

Select

OTULIN / FAM105B Antibody (aa238-287) LS-C201793

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa238-287) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

OTULIN / FAM105B Antibody (aa238-287, HRP) LS-C477345

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa238-287) (HRP) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

OTULIN / FAM105B Antibody (aa238-287, Biotin) LS-C477343

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa238-287) (Biotin) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

OTULIN / FAM105B Antibody (aa238-287, FITC) LS-C477344

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa238-287) (FITC) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

OTULIN / FAM105B Antibody (aa302-352) LS-C763334

Antibody:

OTULIN / FAM105B Rabbit anti-Human Polyclonal (aa302-352) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µl/$295

Select

OTULIN / FAM105B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107322

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.1 kDa

Price:

100 µg/$494

Select

Human OTULIN / FAM105B (Sandwich ELISA) ELISA Kit - LS-F66222

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Price:

1 Plate/$783

Select

Mouse OTULIN / FAM105B (Custom) ELISA Kit - LS-F65503

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

Select

Human OTULIN / FAM105B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G95030

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.1 kDa

Price:

20 µg/$150

Select

Human OTULIN / FAM105B Protein (Recombinant His) (aa1-250) - LS-G141131

Source:

E. coli

Sequence Length:

249 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

27.5 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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