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Osteocalcin Antibody (aa15‑31) LS‑C41702
Osteocalcin antibody LS-C41702 is an unconjugated mouse monoclonal antibody to Osteocalcin from human, rat, bovine and other species. Validated for ELISA.
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Species:
Bovine, Human, Rat, Dog, Goat, Pig, Rabbit, Sheep, Chicken
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Product Description
Osteocalcin antibody LS-C41702 is an unconjugated mouse monoclonal antibody to Osteocalcin from human, rat, bovine and other species. Validated for ELISA.
About Osteocalcin
Osteocalcin (BGLAP) is secreted by osteoblasts and plays a role in metabolic regulation. It is pro-osteoblastic (bone-building). It is also implicated in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin.
P02818
BG752923
NP_954642.1
BGLAP Antibody, Bone Gla protein Antibody, BGP Antibody, OC Antibody, Osteocalcin Antibody
Specifications
Target
Bovine Osteocalcin
Host
Mouse
Reactivity
Bovine, Human, Rat, Pig, Rabbit
(tested or 100% immunogen sequence identity)
Clonality
IgG2a
Monoclonal
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
- ELISA
Immunogen
Osteocalcin antibody was raised against native bovine osteocalcin.
Epitope
aa15-31
Specificity
recognizes intact human and bovine osteocalcin in a "2 site" assay and reacts with osteocalcin fragments corresponding to amino acids 15-31 and 20-43 of the native molecule. It does not recognize fragments representing amino acids 1-19 or 7-19 or intact bovine osteocalcin. Osteocalcin (Bone Gla Protein) is a 49 amino acid single chain vitamin K dependent protein (MW 5.8 kD), made by osteoblasts that is a major component of the non-collagenous bone matrix. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Pageta€™s disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency.
Presentation
PBS, 0.09% sodium azide.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
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Requested From:
Date Requested: 6/19/2018
Date Requested: 6/19/2018
