The Immunohistochemistry Antibody Company
|Bovine, Human, Rat, Pig, Rabbit (tested or 100% immunogen sequence identity)|
|Protein A purified|
|Osteocalcin antibody was raised against native bovine osteocalcin.|
|recognizes intact human and bovine osteocalcin in a "2 site" assay and reacts with osteocalcin fragments corresponding to amino acids 15-31 and 20-43 of the native molecule. It does not recognize fragments representing amino acids 1-19 or 7-19 or intact bovine osteocalcin. Osteocalcin (Bone Gla Protein) is a 49 amino acid single chain vitamin K dependent protein (MW 5.8 kD), made by osteoblasts that is a major component of the non-collagenous bone matrix. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Pageta€™s disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency.|
|PBS, 0.09% sodium azide.|
|For research use only.|
BGLAP Antibody, Bone Gla protein Antibody, BGP Antibody, OC Antibody, Osteocalcin AntibodyOsteocalcin (BGLAP) is secreted by osteoblasts and plays a role in metabolic regulation. It is pro-osteoblastic (bone-building). It is also implicated in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin.