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Anti-OPTN / Optineurin Antibody (aa575-591) IHC-plus™ LS-B1611

Note: This antibody replaces LS-C11174

Ordering

Wt. Vol. Conc. Price
- 1 ea - $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular OPTN / Optineurin Antibodies

Anti-OPTN / Optineurin Antibody (aa115-130) IHC-plus™ LS-B2096
Rabbit Polyclonal (IgG) to Human OPTN / Optineurin
Human, Monkey
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-OPTN / Optineurin Antibody (aa559-575) IHC-plus™ LS-B3065
Rabbit Polyclonal to Human OPTN / Optineurin
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-OPTN / Optineurin Antibody (aa70-96, FITC) LS-C226931
Rabbit Polyclonal (IgG) to Human OPTN / Optineurin
Human
Western blot, ELISA
FITC Conjugated

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human OPTN / Optineurin
Human, Monkey, Mouse, Rat, Bat, Dog, Horse, Rabbit
IHC - Paraffin, Western blot
Unconjugated

Details

Human OPTN / Optineurin
Rabbit
Human, Monkey, Mouse, Rat, Bat, Dog, Horse, Rabbit (tested or 100% immunogen sequence identity)
Hamster (at least 90% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (10 µg/ml)
  • Western blot

Specificity and Use

OPTN / Optineurin antibody was raised against human, mouse, and rat (100% identity) optineurin amino acids 575-591 (GEVLPDIDTLQIHVMDC). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Elephant, Panda, Horse, Rabbit (100%); Hamster, Opossum (94%); Bovine, Pig, Platypus (88%); Turkey, Chicken, Lizard, Zebrafish (82%).
aa575-591
human, murine, and rat (100% identity) optineurin amino acids 575-591 (GEVLPDIDTLQIHVMDC)
Immunohistochemistry: LS-B1611 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B1611 was determined to be 10 ug/ml.

Packaging

TBS, pH 7.4, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About OPTN / Optineurin

Q96CV9 NM_021980 NP_068815.2

OPTN Antibody, ALS12 Antibody, E3-14.7K-interacting protein Antibody, FIP-2 Antibody, HIP-7 Antibody, HYPL Antibody, Huntingtin yeast partner L Antibody, HIP7 Antibody, TFIIIA-INTP Antibody, NEMO-related protein Antibody, NRP Antibody, Optineurin Antibody, FIP2 Antibody, GLC1E Antibody

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death.

Immunohistochemistry

Immunohistochemistry
Anti-Optineurin antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1611 concentration 10 ug/ml.

Western blot

Western blot
Western blot of Optineurin antibody LS-B1611.

Requested From: United States
Date Requested: 12/10/2016

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