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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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OPG / Osteoprotegerin Antibody (clone R110) LS‑C179554
Osteoprotegerin antibody LS-C179554 is an unconjugated mouse monoclonal antibody to human Osteoprotegerin (OPG). Validated for WB.
Catalog
Size
Price
LS-C179554-100
100 µg (1 mg/ml)
Unavailable

Popular OPG / Osteoprotegerin Products

HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Anti-Osteoprotegerin / OPG antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11213 dilution 1:200.
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Immunohistochemical analysis of Osteoprotegerin staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Antibody
Species: Human
Applications: IHC, IHC - Paraffin, IHC - Frozen, ICC, Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry

Product Description

Osteoprotegerin antibody LS-C179554 is an unconjugated mouse monoclonal antibody to human Osteoprotegerin (OPG). Validated for WB.
About OPG / Osteoprotegerin
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. O00300 NM_002546 NP_002537.3

TNFRSF11B Antibody, OCIF Antibody, OPG Antibody, Osteoprotegerin Antibody, TR1 Antibody


Specifications

Target
Human OPG / Osteoprotegerin
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal [R110]
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
  • Western blot (5 µg/ml)
Immunogen
OPG.
Specificity
Human Osteoprotegerin / OPG
Presentation
PBS, pH 7.2, 50% glycerol
Storage
Store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Flow Cytometry

Flow Cytometry

Flow Cytometry

Flow Cytometry



Requested From: 
Date Requested: 6/18/2018

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