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Anti-OPG / Osteoprotegerin Antibody (clone R110) LS-C179554

Catalog	Size	Price
LS-C179554-100	100 µg (1 mg/ml)	Unavailable

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Anti-OPG / Osteoprotegerin Antibody (clone R110) LS-C179554

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Anti-OPG / Osteoprotegerin Antibody (aa20-37, clone 98A1071, Azide-free) LS-C368275

Antibody:	Mouse Monoclonal [clone 98A1071] (IgG1,k) to Human OPG / Osteoprotegerin
Reactivity:	Human
Application:	IHC - Paraffin, IHC - Frozen, ICC, Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry
Format:	Unconjugated, Azide-free

Antibody:	Mouse Monoclonal [clone R110] (IgG1,k) to Human OPG / Osteoprotegerin
Reactivity:	Human
Application:	Western blot
Format:	Unconjugated

Details

Target:	Human OPG / Osteoprotegerin
Host:	Mouse
Reactivity:	Human (tested or 100% immunogen sequence identity)
Clonality:	IgG1,k Monoclonal [R110]
Conjugations:	Unconjugated
Purification:	Protein A purified
Modifications:	Unmodified

Applications

Approved:

Western blot (5 µg/ml)

Specificity and Use

Immunogen:	OPG.
Specificity:	Human Osteoprotegerin / OPG

Packaging

Presentation:	PBS, pH 7.2, 50% glycerol
Storage:	Store at -20°C.
Restrictions:	For research use only.

About OPG / Osteoprotegerin

Uniprot: O00300 NCBI: NM_002546 NP_002537.3

Synonyms: TNFRSF11B Antibody, OCIF Antibody, OPG Antibody, Osteoprotegerin Antibody, TR1 Antibody

Description: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

(More About OPG / Osteoprotegerin)

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Date Requested: 8/20/2017

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