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Anti-OPG / Osteoprotegerin Antibody (aa20-37, clone 98A1071) IHC-plus™ LS-B2078

Note: This antibody replaces LS-C539, LS-C73953, LS-C73952


Wt. Vol. Conc. Price
50 µg - 0.5 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular OPG / Osteoprotegerin Antibodies

Anti-OPG / Osteoprotegerin Antibody (aa20-37, clone 98A1071) IHC-plus™ LS-B2078
Mouse Monoclonal [clone 98A1071] (IgG) to Human OPG / Osteoprotegerin
IHC - Paraffin, Western blot
Immunohistochemistry Image
Anti-OPG / Osteoprotegerin Antibody (aa1-50) IHC-plus™ LS-B11213
Rabbit Polyclonal to Human OPG / Osteoprotegerin
Human, Mouse, Rat
IHC - Paraffin, Immunofluorescence, Western blot
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 98A1071] (IgG) to Human OPG / Osteoprotegerin
IHC - Paraffin, Western blot


Human OPG / Osteoprotegerin
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
IgG Monoclonal [98A1071]
Protein G purified


  • IHC - Paraffin (5 µg/ml)
  • Western blot

Specificity and Use

OPG / Osteoprotegerin antibody was raised against a peptide corresponding to the amino acids 20-37 TQETFPPKYLHYDEETSH of human OPG. The specificity was tested on recombinant OPG by western blot analysis. Percent identity by BLAST analysis: Human, Gibbon (100%); Monkey (94%); Marmoset, Panda, Dog, Horse, Pig, Opossum (89%); Mouse, Rat, Elephant, Bovine (83%).
The Osteoprotegerin antibody, clone 98A1071, detects all forms of Osteoprotegerin including monomeric, dimeric and Osteoprotegerin bound to RANKL (Vandooren, 2008) as well as Osteoprotegerin bound to TRAIL (Sandra, 2006).
Immunohistochemistry: LS-B2078 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2078 was determined to be 5 ug/ml.


PBS, 0.05% BSA, 0.05% sodium azide. Sourced in TCS.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About OPG / Osteoprotegerin

O00300 NM_002546 NP_002537.3

TNFRSF11B Antibody, OCIF Antibody, OPG Antibody, Osteoprotegerin Antibody, TR1 Antibody

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.


Anti-Osteoprotegerin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2078 concentration 5 ug/ml.


Anti-Osteoprotegerin antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2078 concentration 5 ug/ml.

Western blot

Western blot
Western blot analysis for OPG with antibody antibody against Daudi cell lysate. Daudi cell lysate blot was incubated with antibody at a dilution of 1 µg/ml and the immunoreactivity was detected by enhanced chemiluminescence.

Requested From: United States
Date Requested: 10/28/2016

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