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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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OAS1 Antibody (aa302‑330) LS‑C100473
OAS1 antibody LS-C100473 is an unconjugated rabbit polyclonal antibody to OAS1 from human and mouse. Validated for IHC and WB. Cited in 3 publications.
Catalog
Size
Price
LS-C100473-400
400 µl
Unavailable

Popular OAS1 Products

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Anti-OAS1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6731 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Immunohistochemistry - Paraffin Image
Species: Human
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Product Description

OAS1 antibody LS-C100473 is an unconjugated rabbit polyclonal antibody to OAS1 from human and mouse. Validated for IHC and WB. Cited in 3 publications.
About OAS1
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. P00973 NM_016816 NP_058132.2

OAS1 Antibody, 2,5-oligo A synthetase 1 Antibody, 2-5A synthetase 1 Antibody, 2-5A synthase 1 Antibody, 2-5-oligoadenylate synthase 1 Antibody, E18/E16 Antibody, OIASI Antibody, OIAS Antibody, p46/p42 OAS Antibody, IFI-4 Antibody


Specifications

Target
Human OAS1
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Ammonium sulfate precipitation
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:10 - 1:50)
  • Western blot (1:1000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Blocking Peptide
LS-E8138 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C100473. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa302-330
Specificity
This OAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human OAS1.
Presentation
PBS, 0.09% sodium azide
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

Publications (3)

1
Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:1828-33. [PubMed:16446426] [PMC:PMC1413670]
2
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L. Han JQ, Townsend HL, Jha BK, Paranjape JM, Silverman RH, Barton DJ. Journal of virology. 2007 81:5561-72. [PubMed:17344297] [PMC:PMC1900262]
3
Azithromycin induces anti-viral responses in bronchial epithelial cells. Gielen V, Johnston SL, Edwards MR. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2010 36:646-54. [PubMed:20150207]

Customer Reviews (0)


Images


Immunohistochemistry

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Western blot

The anti-OAS1 antibody is used in Western blot to detect OAS1 in mouse liver lysate.
The anti-OAS1 antibody is used in Western blot to detect OAS1 in mouse liver lysate.

Immunohistochemistry

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Western blot

The anti-OAS1 antibody is used in Western blot to detect OAS1 in mouse liver lysate.
The anti-OAS1 antibody is used in Western blot to detect OAS1 in mouse liver lysate.

Immunohistochemistry

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Western blot

The anti-OAS1 antibody is used in Western blot to detect OAS1 in mouse liver lysate.
The anti-OAS1 antibody is used in Western blot to detect OAS1 in mouse liver lysate.

Immunohistochemistry

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Western blot

The anti-OAS1 antibody is used in Western blot to detect OAS1 in mouse liver lysate.
The anti-OAS1 antibody is used in Western blot to detect OAS1 in mouse liver lysate.


Requested From: 
Date Requested: 6/25/2018

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