Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
GST-trkA fusion protein (20-355aa) Epitope: Extracellular, N-terminal region.
Recognizes human trkA, trkB and trkC. Reactivity has also been seen with transfected rat trkA, trkB and trkC. Reactivity has been shown with glycosylated (gp140trk), partially glycosylated (gp110 trk) and unglycosylated (gp80trk) trk.
Immunohistochemistry: LS-B2424 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2424 was determined to be 2.5-10 ug/ml.
PBS, pH 7.4, 0.1% sodium azide, 40% glycerol.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.
About NTRK / Neurotrophic Tyrosine Kinase Receptor